Eplerenone

Generic Name
Eplerenone
Brand Names
Inspra
Drug Type
Small Molecule
Chemical Formula
C24H30O6
CAS Number
107724-20-9
Unique Ingredient Identifier
6995V82D0B
Background

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the ef...

Indication

For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.

Associated Conditions
Hypertension, LVEF <40% Congestive heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class II)
Associated Therapies
-

Defining Strategies for Improving Endothelial and Fibrinolytic Dysfunction in Obesity

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2008-02-06
Last Posted Date
2017-08-11
Lead Sponsor
Vanderbilt University
Target Recruit Count
4
Registration Number
NCT00608465
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?

First Posted Date
2007-11-06
Last Posted Date
2007-11-06
Lead Sponsor
Shaare Zedek Medical Center
Target Recruit Count
27
Registration Number
NCT00553722
Locations
🇮🇱

Shaare Zedek Medical Center, Jerusalem, Israel

The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure

First Posted Date
2007-07-23
Last Posted Date
2009-02-11
Lead Sponsor
St Vincent's University Hospital, Ireland
Target Recruit Count
43
Registration Number
NCT00505336
Locations
🇮🇪

St Vincent's University Hospital, Ballsbridge, Dublin, Ireland

Inhibition of Aldosterone in Patients With Chronic Renal Disease

Phase 4
Completed
Conditions
Interventions
First Posted Date
2007-02-02
Last Posted Date
2012-02-08
Lead Sponsor
Lene Boesby
Target Recruit Count
42
Registration Number
NCT00430924
Locations
🇩🇰

Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark

🇩🇰

Herlev Hospital, Herlev, Denmark

Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives.

First Posted Date
2006-12-05
Last Posted Date
2007-03-07
Lead Sponsor
Erasmus Medical Center
Target Recruit Count
500
Registration Number
NCT00407784
Locations
🇳🇱

Academical Medical Center, Amsterdam, Netherlands

🇳🇱

Erasmus Medical Center, Rotterdam, Netherlands

🇳🇱

Sint Franciscus Gasthuis, Rotterdam, Netherlands

and more 10 locations

CMR to Assess Fibrosis in Cardiomyopathy Using Eplerenone

Phase 4
Completed
Conditions
Interventions
First Posted Date
2006-11-22
Last Posted Date
2021-09-21
Lead Sponsor
Royal Brompton & Harefield NHS Foundation Trust
Target Recruit Count
42
Registration Number
NCT00401856
Locations
🇬🇧

Royal Brompton & Harefield NHS Trust, London, United Kingdom

Eplerenone, ACE Inhibition and Albuminuria

First Posted Date
2006-04-17
Last Posted Date
2012-05-28
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
30
Registration Number
NCT00315016
Locations
🇳🇱

Jeroen Bosch Hospital, 's-Hertogenbosch, Noord Brabant, Netherlands

🇳🇱

University Medical Center Nijmegen St Radboud, Nijmegen, Netherlands

Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2006-02-17
Last Posted Date
2017-01-27
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
11
Registration Number
NCT00293150
Locations
🇺🇸

The Cleveland Clinic, Cleveland, Ohio, United States

A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines

Phase 3
Completed
Conditions
Interventions
First Posted Date
2005-10-04
Last Posted Date
2020-12-22
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
2743
Registration Number
NCT00232180
Locations
🇻🇪

Pfizer Investigational Site, Caracas, Estado Miranda, Venezuela

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