MedPath

Gelatin

Generic Name
Gelatin
Drug Type
Small Molecule
CAS Number
9000-70-8
Unique Ingredient Identifier
2G86QN327L

Overview

Gelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former. As a thermoreversible hydrocolloid with a small gap between its melting and gelling temperatures, gelatin provides unique advantages over carbohydrate-based gelling agents. Gelatin is mainly produced from porcine skin, and cattle hides and bones. Some alternative raw substances have recently garnered attention from both researchers and the industry not only because they overcome religious concerns shared by both Jews and Muslims but also because they may provide scientific advantages over gelatins from mammal origins. Fish skins from a number of fish species a type of substance that has been comprehensively studied as a source for gelatin production. Fish skins have a significant potential for the production of high-quality gelatin with different melting and gelling temperatures over a much larger range than mammalian gelatins but have a sufficiently high level of gel strength and viscosity. Interestingly, horse gelatin has been studied and it was found that in the horse, gelatin influences the homeostasis of the amino acids required for cartilage synthesis . An increasing number of novel applications have been found for collagen and gelatin. Gelatin is generally recognized as safe (GRAS) by the FDA to be a non-hazardous food or food ingredient. The FDA withdrew its approval for the use of all intravenous drug products containing gelatin. Gelatin continues to be approved for other routes of administration.

Background

Gelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former. As a thermoreversible hydrocolloid with a small gap between its melting and gelling temperatures, gelatin provides unique advantages over carbohydrate-based gelling agents. Gelatin is mainly produced from porcine skin, and cattle hides and bones. Some alternative raw substances have recently garnered attention from both researchers and the industry not only because they overcome religious concerns shared by both Jews and Muslims but also because they may provide scientific advantages over gelatins from mammal origins. Fish skins from a number of fish species a type of substance that has been comprehensively studied as a source for gelatin production. Fish skins have a significant potential for the production of high-quality gelatin with different melting and gelling temperatures over a much larger range than mammalian gelatins but have a sufficiently high level of gel strength and viscosity. Interestingly, horse gelatin has been studied and it was found that in the horse, gelatin influences the homeostasis of the amino acids required for cartilage synthesis . An increasing number of novel applications have been found for collagen and gelatin. Gelatin is generally recognized as safe (GRAS) by the FDA to be a non-hazardous food or food ingredient. The FDA withdrew its approval for the use of all intravenous drug products containing gelatin. Gelatin continues to be approved for other routes of administration.

Indication

Gelatin is used for weight loss and for treating osteoarthritis, rheumatoid arthritis, and brittle bones (osteoporosis). Some people also use it for strengthening bones, joints, and fingernails. Gelatin is also used for improving hair condition and to shorten the recovery after exercise and sports-related injury . Gelatin is used in preparations of foods, cosmetics, and medicine . Plasma volume expander in hypovolaemic shock . Haemostatic . Gelatin-based hydrogels are being used in drug delivery and tissue engineering because they are able to promote cell adhesion and proliferation. In addition, these hydrogels can be used as wound dressings because of their attractive fluid absorbance properties. Manufacturing technologies such as ultraviolet stereolithography and two-photon polymerization can be used to prepare structures containing photosensitive gelatin-based hydrogels .

Associated Conditions

  • Hypovolaemia

Clinical Trials

Title
Posted
Study ID
Phase
Status
Sponsor
2024/05/30
Not Applicable
Active, not recruiting
Recep Tayyip Erdogan University
2023/12/19
Phase 1
Completed
2023/08/02
Not Applicable
Not yet recruiting
Fifth Affiliated Hospital of Guangzhou Medical University
2020/05/27
Not Applicable
Completed
2018/01/18
Phase 4
UNKNOWN
Karim ehab gerges
2017/06/21
Phase 2
Completed
Alborz Medical University
2016/03/22
Phase 4
Terminated
2014/10/31
Phase 1
Completed
Medical University of Warsaw
2014/05/15
Early Phase 1
Completed
2014/01/20
Phase 1
Completed

FDA Approved Products

Product Name
Manufacturer
Route
Strength
Approved
NDC Code
INTRAVENOUS
4.5 mg in 1 1
2012/12/02
51808-220

EMA Approved Products

Medicine Name
EMA Number
Auth. Holder
Country
Drug Type
Status
Issued
Opinion
Revision

No EMA products found

No EMA products found for this drug

HSA Approved Products

Product Name
Manufacturer
Dosage Form
Strength
Approved
Approval No.

No HSA products found

No HSA products found for this drug

NMPA Approved Products

Product Name
Approval No.
Manufacturer
Dosage Form
Trade Name
Strength
Type
Status
Date
Import

No NMPA products found

No NMPA products found for this drug

PPB Approved Products

Product Name
Registration Code
Company
Category
Sale Type
Reg. Date

No PPB products found

No PPB products found for this drug

TGA Approved Products

Product Name
ARTG ID
Sponsor
Status
Reg. Date
Ingredient
443659
All Natural Pharmacy Pty Ltd
Active
2024/03/13
hydrolysed gelatin
199296
Active
2012/07/11
Gelatin
388477
Active
2022/05/16
hydrolysed gelatin
299910
Active
2018/02/22
hydrolysed gelatin
324701
Active
2019/10/11
hydrolysed gelatin
291808
Active
2017/07/21
hydrolysed gelatin
402095
Active
2023/01/11
hydrolysed gelatin
325696
Active
2019/10/29
Gelatin
325708
Active
2019/10/29
Gelatin
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