MedPath

Penciclovir

Generic Name
Penciclovir
Brand Names
Denavir
Drug Type
Small Molecule
Chemical Formula
C10H15N5O3
CAS Number
39809-25-1
Unique Ingredient Identifier
359HUE8FJC
Background

Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. Displaying low toxicity and good selectivity, penciclovir is a nucleoside analogue.

Indication

Used to treat recurrent cold sores on the lips and face from various herpesvirus invections.

Associated Conditions
Cold Sore

Safety and Immunogenicity of PCV-LITE, a Low-dose of Pneumococcal Conjugate Vaccine With LiteVax Adjuvant

Phase 1
Not yet recruiting
Conditions
Vaccine Reaction
Interventions
Biological: PCV-LITE
Biological: PCV-LITE+LVA
Biological: PCV20+LVA
First Posted Date
2025-05-22
Last Posted Date
2025-05-22
Lead Sponsor
LiteVax BV
Target Recruit Count
80
Registration Number
NCT06986239

A Study on the Immune Response and Safety of the Second Dose of an Investigational Chickenpox Vaccine When Given to Healthy Children 3 Months After a First Dose at 12 to 15 Months of Age

Phase 3
Not yet recruiting
Conditions
Chickenpox
Interventions
First Posted Date
2025-02-03
Last Posted Date
2025-02-03
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
600
Registration Number
NCT06806137

A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age

Phase 3
Recruiting
Conditions
Chickenpox
Interventions
Biological: Investigational varicella vaccine_Lot 1
Biological: Investigational varicella vaccine_Lot 2
Biological: Investigational varicella vaccine_Lot 3
Biological: Marketed varicella vaccine_Lot 1
Biological: Marketed varicella vaccine_Lot 2
First Posted Date
2024-12-18
Last Posted Date
2025-03-07
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
1840
Registration Number
NCT06740630
Locations
🇺🇸

GSK Investigational Site, Layton, Utah, United States

A Study on the Safety of an Investigational Chickenpox Vaccine, When Given to Healthy Children, 12 to 15 Months of Age

Phase 3
Recruiting
Conditions
Chickenpox
Interventions
Biological: Investigational varicella vaccine
Biological: Marketed varicella vaccine
Biological: Measles, mumps, and rubella vaccine
First Posted Date
2024-11-18
Last Posted Date
2025-01-20
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
750
Registration Number
NCT06693895
Locations
🇺🇸

GSK Investigational Site, West Covina, California, United States

Immunogenicity and Clinical Efficacy of 20-valent Pneumococcal Conjugate Vaccine (PCV20) in Lymphoma Survivors After Treatment With Anti-CD20 Therapy

Phase 4
Recruiting
Conditions
Lymphoma
Interventions
First Posted Date
2023-09-21
Last Posted Date
2025-05-14
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
30
Registration Number
NCT06049134
Locations
🇺🇸

M D Anderson Cancer Center, Houston, Texas, United States

Study to Assess the Immune Response, the Safety and the Reactogenicity of Respiratory Syncytial Virus (RSV) Prefusion Protein 3 Older Adult (OA) (RSVPreF3 OA) Investigational Vaccine When co Administered With PCV20 in Older Adults

Phase 3
Completed
Conditions
Respiratory Syncytial Virus Infections
Interventions
First Posted Date
2023-05-30
Last Posted Date
2025-05-18
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
1113
Registration Number
NCT05879107
Locations
🇪🇸

GSK Investigational Site, Valencia, Spain

Safety and Immunogenicity of V116 in Pneumococcal Vaccine-naïve Adults (V116-003, STRIDE-3)

Phase 3
Completed
Conditions
Pneumococcal Infection
Interventions
First Posted Date
2022-06-21
Last Posted Date
2024-10-26
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
2663
Registration Number
NCT05425732
Locations
🇺🇸

Baptist Health Center For Clinical Research ( Site 0019), Little Rock, Arkansas, United States

🇺🇸

Millennium Clinical Trials ( Site 0013), Simi Valley, California, United States

🇺🇸

Alliance for Multispecialty Research, LLC ( Site 0015), Coral Gables, Florida, United States

and more 109 locations

A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas).

Phase 3
Recruiting
Conditions
Oligodendroglioma
Interventions
Drug: CETEG
Radiation: RT
First Posted Date
2022-04-15
Last Posted Date
2025-01-22
Lead Sponsor
University Hospital Heidelberg
Target Recruit Count
406
Registration Number
NCT05331521
Locations
🇩🇪

University Hospital Cologne, Neurosurgery, Cologne, Germany

🇩🇪

University Hospital Leipzig, Radiation Therapy, Leipzig, Germany

🇩🇪

Helios Hospital Schwerin, Neurosurgery, Schwerin, Germany

and more 16 locations

A Randomized Trial of Delayed Radiotherapy in Patients Low-grade Oligodendrogliomas Requiring a Treatment Other Than Surgery

Phase 3
Recruiting
Conditions
Oligodendroglioma
Low-grade Oligodendroglioma
1p19q Codeletion
Interventions
Drug: Radiotherapy and PCV chemotherapy
First Posted Date
2021-01-11
Last Posted Date
2025-03-13
Lead Sponsor
Hospices Civils de Lyon
Target Recruit Count
280
Registration Number
NCT04702581
Locations
🇫🇷

CHU d'Amiens-Picardie Site Sud, Amiens, France

🇫🇷

Institut de Cancerologie de l'Ouest, Saint-Herblain, France

🇫🇷

CHU de Bordeaux Hôpital Saint André, Bordeaux, France

and more 22 locations
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