Nimodipine

Generic Name: Nimodipine

Brand Names: Nimotop, Nymalize

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆N_₂O_₇

CAS Number: 66085-59-4

Unique Ingredient Identifier: 57WA9QZ5WH

Background: Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation. Nimodipine is used to as an adjunct to improve the neurologic outcome following subarachnoid hemorrhage from ruptured intracranial aneurysm.

Indication: For use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage (SAH) from ruptured intracranial berry aneurysms by reducing the incidence and severity of ischemic deficits.

Associated Conditions: Delayed Ischemic Neurological Deficit

Clinical Trials

Effects of Nimodipine on Alcohol Drinking

Phase 2

Not yet recruiting

Conditions: Alcohol Use Disorder

Interventions: Drug: Nimodipine

First Posted Date: 2025-03-28

Last Posted Date: 2025-03-28

Lead Sponsor: Yale University

Target Recruit Count: 5

Registration Number: NCT06900998

Locations: 🇺🇸
Yale University School of Medicine (Connecticut Mental Health Center), New Haven, Connecticut, United States

Safety and Tolerability of GTX-104 Compared With Oral Nimodipine in Patients With aSAH

Phase 3

Active, not recruiting

Conditions: Aneurysmal Subarachnoid Hemorrhage (aSAH)

Interventions: Drug: Nimotop 30 MG Oral Capsule
Drug: GTX-104

First Posted Date: 2023-08-16

Last Posted Date: 2024-10-01

Lead Sponsor: Acasti Pharma Inc.

Target Recruit Count: 100

Registration Number: NCT05995405

Locations: 🇺🇸
The University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸
Brain and Spine Neurological Institute, Phoenix, Arizona, United States
🇺🇸
Community Regional Medical Center, Fresno, California, United States

and more 19 locations

Relative Bioavailability of Intravenous GTX-104 Compared to Oral Nimodipine Capsules in Healthy Subjects

Phase 1

Completed

Conditions: Aneurysmal Subarachnoid Hemorrhage

Interventions: Drug: Nimodipine Capsules
Drug: GTX-104

First Posted Date: 2022-06-14

Last Posted Date: 2023-08-31

Lead Sponsor: Acasti Pharma Inc.

Target Recruit Count: 58

Registration Number: NCT05418348

Locations: 🇨🇦
Clinical Research Unit, Montréal, Canada

Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy

Phase 2

Completed

Conditions: Vascular Spasm After Traumatic Subarachnoidhaemorrhage
Milrinone
Oral Nimodipine

Interventions: Drug: Oral Nimodipine and milrinone
Drug: nimodipine

First Posted Date: 2021-11-23

Last Posted Date: 2022-05-25

Lead Sponsor: Zagazig University

Target Recruit Count: 30

Registration Number: NCT05131867

Locations: 🇪🇬
Aculty of Medicine,Zagazig University, Zagazig, El Sharkia, Egypt
🇪🇬
Faculty of Medicine,Zagazig University, Zagazig, Zagazig, Elsharkia,egypt, Egypt