丙米嗪 (Tofranil)

概览

Imipramine is a tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.

作用机制

Imipramine works by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and serotonin . It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter reducing the reuptake of norepinephrine and serotonin by neurons. Depression has been linked to a lack of stimulation of the post-synaptic neuron by norepinephrine and serotonin . Slowing the reuptake of these neurotransmitters increases their concentration in the synaptic cleft, producing knock-on effects in protein kinase signalling which is thought to contribute to changes in neurotransmission and brain physiology which relieves symptoms of depression .

适应症

For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older . May also be used off-label to manage panic disorders with or without agoraphobia, as a second line agent for ADHD in children and adolescents, to manage bulimia nervosa, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, for the treatment of acute stress disorder and posttraumatic stress disorder, and for symptomatic treatment of postherpetic neuralgia and painful diabetic neuropathy .

• Attention Deficit Hyperactivity Disorder (ADHD)
• Bulimia Nervosa
• Depression
• Enuresis
• Neuropathic Pain
• Panic Disorder