Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Indicated for:
1) Prophylaxis and treatment of venous thromboembolism and related pulmonary embolism.
2) Prophylaxis and treatment of thromboembolism associated with atrial fibrillation.
3) Prophylaxis and treatment of thromboembolism associated with cardiac valve replacement.
4) Use as adjunct therapy to reduce mortality, recurrent myocardial infarction, and thromboembolic events post myocardial infarction.
Off-label uses include:
1) Secondary prevention of stroke and transient ischemic attacks in patients with rheumatic mitral valve disease but without atrial fibrillation.
Federal State Institution Academician E.N.Meshalkin Novosibirsk State Research Institute Of Circulation Pathology Rusmedtechnology, Novosibirsk, Russian Federation
Northwestern University, Chicago, Illinois, United States
Nephrology & Hypertension Associates, Tupelo, Mississippi, United States
Nuren Medical and Research Center, Miami, Florida, United States
IRCCS Policlinico San Matteo, Pavia, Italy
Caritas Hospital, Kottayam, India
Mazumdar Shaw Medical centre, Bangalore, India
Nizam's Institute of Medical Sciences, Hyderabad, India
Sanford Health, Fargo, North Dakota, United States
Department of Radiology, Guangzhou, Guangdong, China
Baptist Memorial Hospital, Memphis, Tennessee, United States
Westchester Medical Center, Valhalla, New York, United States
Temple University Hospital, Philadelphia, Pennsylvania, United States
Mayo Clinic, Rochester, Minnesota, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
UCLA, Los Angeles, California, United States
1346.22.1 Boehringer Ingelheim Investigational Site, Biberach, Germany
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