Overview
Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Indication
Indicated for: 1) Prophylaxis and treatment of venous thromboembolism and related pulmonary embolism. 2) Prophylaxis and treatment of thromboembolism associated with atrial fibrillation. 3) Prophylaxis and treatment of thromboembolism associated with cardiac valve replacement. 4) Use as adjunct therapy to reduce mortality, recurrent myocardial infarction, and thromboembolic events post myocardial infarction. Off-label uses include: 1) Secondary prevention of stroke and transient ischemic attacks in patients with rheumatic mitral valve disease but without atrial fibrillation.
Associated Conditions
- Myocardial Infarction
- Pulmonary Embolism
- Stroke
- Systemic Embolism
- Thromboembolism
- Transient Ischemic Attack
- Venous Thrombosis (Disorder)
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2015/12/28 | N/A | Completed | |||
2015/12/15 | N/A | Completed | |||
2015/12/01 | Phase 1 | Completed | |||
2015/10/14 | Phase 1 | Completed | |||
2015/09/28 | Phase 4 | Terminated | Electrophysiology Research Foundation | ||
2015/09/09 | Phase 3 | UNKNOWN | |||
2015/09/04 | Phase 1 | Completed | |||
2015/08/24 | Phase 1 | Completed | |||
2015/08/13 | Phase 3 | UNKNOWN | Espero Biopharma | ||
2015/07/23 | Phase 4 | Terminated | Susan Smyth |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Aphena Pharma Solutions - Tennessee, LLC | 71610-173 | ORAL | 5 mg in 1 1 | 10/24/2018 | |
| A-S Medication Solutions | 50090-2646 | ORAL | 1 mg in 1 1 | 4/8/2025 | |
| A-S Medication Solutions | 50090-2039 | ORAL | 5 mg in 1 1 | 7/26/2018 | |
| Northwind Pharmaceuticals, LLC | 51655-282 | ORAL | 4 mg in 1 1 | 3/23/2015 | |
| Aphena Pharma Solutions - Tennessee, LLC | 43353-053 | ORAL | 7.5 mg in 1 1 | 4/25/2015 | |
| Aphena Pharma Solutions - Tennessee, LLC | 43353-021 | ORAL | 2 mg in 1 1 | 4/25/2015 | |
| NuCare Pharmaceuticals,Inc. | 68071-5003 | ORAL | 3 mg in 1 1 | 2/19/2021 | |
| Sun Pharmaceutical Industries, Inc. | 51672-4029 | ORAL | 2.5 mg in 1 1 | 12/21/2023 | |
| Taro Pharmaceuticals U.S.A., Inc. | 51672-4029 | ORAL | 2.5 mg in 1 1 | 12/21/2023 | |
| Physicians Total Care, Inc. | 54868-4402 | ORAL | 4 mg in 1 1 | 2/9/2012 |
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| No EMA approvals found for this drug. | |||
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