Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain

First Posted Date
2011-08-16
Last Posted Date
2012-11-06
Lead Sponsor
Meir Medical Center
Target Recruit Count
80
Registration Number
NCT01417923
Locations
🇮🇱

Meir Medical Center, Kfar Saba, Israel

Vitamin D Supplementation in Systemic Lupus Erythematosus

Completed
Conditions
First Posted Date
2011-08-10
Last Posted Date
2011-11-24
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
20
Registration Number
NCT01413230
Locations
🇫🇷

Chu Pitie Salpetriere, Paris, France

🇫🇷

Nathalie Costedoat-Chalumeau, Paris, France

🇫🇷

Hopital la Pitie Salpétrière, Paris, France

Vitamin D Supplementation on Cardiovascular Risk Factors

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-08-09
Last Posted Date
2017-12-12
Lead Sponsor
Florida International University
Target Recruit Count
92
Registration Number
NCT01412710
Locations
🇺🇸

Human Nutrition Laboratory, Florida International University, Miami, Florida, United States

Alzheimer's Disease - Input of Vitamin D With mEmantine Assay

First Posted Date
2011-08-04
Last Posted Date
2016-09-22
Lead Sponsor
University Hospital, Angers
Target Recruit Count
90
Registration Number
NCT01409694
Locations
🇫🇷

University Hospital, Angers, France

High Dose Vitamin D and Calcium for Bone Health in Individuals Initiating HAART

First Posted Date
2011-07-27
Last Posted Date
2018-10-12
Lead Sponsor
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Target Recruit Count
167
Registration Number
NCT01403051
Locations
🇺🇸

Hosp. of the Univ. of Pennsylvania CRS (6201), Philadelphia, Pennsylvania, United States

🇺🇸

Harbor-UCLA Med. Ctr. CRS (603), Torrance, California, United States

🇺🇸

Stanford CRS (501), Palo Alto, California, United States

and more 36 locations

Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA Trial

First Posted Date
2011-07-22
Last Posted Date
2017-04-11
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
26
Registration Number
NCT01400516
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

🇺🇸

University of Massachusetts Medical School, Worcester, Massachusetts, United States

Vitamin D and Staphylococcus Aureus in the Diabetes Study

Phase 3
Completed
Conditions
Interventions
First Posted Date
2011-07-15
Last Posted Date
2012-09-05
Lead Sponsor
University of Tromso
Target Recruit Count
280
Registration Number
NCT01395290
Locations
🇳🇴

University Hospital of North Norway, Tromsø, Norway

Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.

Phase 1
Completed
Conditions
Interventions
First Posted Date
2011-07-15
Last Posted Date
2017-09-29
Lead Sponsor
Hamad Medical Corporation
Target Recruit Count
597
Registration Number
NCT01395589
Locations
🇶🇦

Hamad Medical Corporation, Pediatric Emergency Center,Alsaad., Doha, Qatar

Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-07-11
Last Posted Date
2015-04-17
Lead Sponsor
Medical University of Graz
Target Recruit Count
31
Registration Number
NCT01390480
Locations
🇦🇹

Medical University Graz, Graz, Austria

Pilot Study of Vitamin D Supplementation in Heart Failure

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-07-07
Last Posted Date
2015-06-19
Lead Sponsor
Fraser Health
Target Recruit Count
13
Registration Number
NCT01388855
Locations
🇨🇦

Royal Columbian Hospital, New Westminster, British Columbia, Canada

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