Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Preventive EXACYL® on Perioperative Bleeding During Orthognathism of Maxillary Surgery
- Conditions
- Interventions
- First Posted Date
- 2016-03-08
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- University Hospital, Lille
- Target Recruit Count
- 157
- Registration Number
- NCT02702128
- Locations
- 🇫🇷
Hôpital Roger Salengro, CHRU de Lille, Lille, France
Efficacy of Tranexamic Acid In Reducing Blood Loss During Cesarean Section Because Of Placenta Previa
- Conditions
- Interventions
- First Posted Date
- 2016-02-23
- Last Posted Date
- 2016-02-23
- Lead Sponsor
- Medical Research Council
- Target Recruit Count
- 52
- Registration Number
- NCT02688127
The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery
- First Posted Date
- 2016-02-18
- Last Posted Date
- 2022-04-21
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 87
- Registration Number
- NCT02684851
- Locations
- 🇺🇸
University of Missouri, Columbia, Missouri, United States
🇺🇸Carolinas Medical Center, Charlotte, North Carolina, United States
Ultra-early Tranexamic Acid After Subarachnoid Hemorrhage.
- First Posted Date
- 2016-02-18
- Last Posted Date
- 2020-11-12
- Target Recruit Count
- 955
- Registration Number
- NCT02684812
- Locations
- 🇳🇱
Academic Medical Centre, Amsterdam, Netherlands
The Effect of Tranexamic Acid on Uterine Blood Flow After Vaginal Delivery
- First Posted Date
- 2016-02-09
- Last Posted Date
- 2016-03-01
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 200
- Registration Number
- NCT02678208
- Locations
- 🇪🇬
Assiut university, Assiut, Egypt
Topical (Intra-Articular) Tranexamic Acid and Transfusion Rates Following Hip Hemiarthroplasty
- Conditions
- Interventions
- First Posted Date
- 2016-01-27
- Last Posted Date
- 2021-07-22
- Lead Sponsor
- UConn Health
- Target Recruit Count
- 36
- Registration Number
- NCT02664909
- Locations
- 🇺🇸
University of Connecticut Health Center, Farmington, Connecticut, United States
🇺🇸Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States
A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery
- Conditions
- Interventions
- First Posted Date
- 2016-01-15
- Last Posted Date
- 2024-10-24
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 22
- Registration Number
- NCT02656472
- Locations
- 🇺🇸
Advocate Childrens Hospital, Oak Lawn, Illinois, United States
Safety and Efficacy of Intravenous Tranexamic Acid in Endoscopic Transurethral Resections in Urology
- First Posted Date
- 2016-01-12
- Last Posted Date
- 2016-10-11
- Lead Sponsor
- University Tunis El Manar
- Target Recruit Count
- 131
- Registration Number
- NCT02653261
- Locations
- 🇹🇳
Ali JENDOUBI, Tunis, Tunisia
Platelet Transfusion Requirements in Hematopoietic Transplantation Pilot Study
- First Posted Date
- 2016-01-08
- Last Posted Date
- 2020-05-18
- Lead Sponsor
- Ottawa Hospital Research Institute
- Target Recruit Count
- 100
- Registration Number
- NCT02650791
- Locations
- 🇨🇦
Tom Baker Cancer Centre, Calgary, Alberta, Canada
🇨🇦Hamilton Health Sciences - Juravinski Hospital and Cancer Centre, Hamilton, Ontario, Canada
🇨🇦Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Pre-hospital Administration of Tranexamic Acid for Moderate and Severe Traumatic Brain Injury
- First Posted Date
- 2016-01-01
- Last Posted Date
- 2016-01-01
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT02645552
- Locations
- 🇨🇳
Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China
Drug Development Updates
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