Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Hemostasis in Open Acetabulum and Pelvic Ring Surgery Using Tranexamic Acid
- Conditions
- Interventions
- First Posted Date
- 2014-01-31
- Last Posted Date
- 2018-02-27
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 88
- Registration Number
- NCT02051686
- Locations
- 🇺🇸
University of Missouri, Columbia, Missouri, United States
Tranexamic Acid in Reverse Total Shoulder Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2014-01-23
- Last Posted Date
- 2017-06-19
- Lead Sponsor
- William Beaumont Hospitals
- Target Recruit Count
- 116
- Registration Number
- NCT02043132
- Locations
- 🇺🇸
William Beaumont Hospital, Royal Oak, Michigan, United States
Tranexamic Acid and Thromboelastography During Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2014-01-01
- Last Posted Date
- 2020-10-27
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT02026297
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Prospective Trial of Tranexamic Acid in Cardiac Surgery
- First Posted Date
- 2013-11-28
- Last Posted Date
- 2016-02-26
- Lead Sponsor
- Hongwen Ji
- Target Recruit Count
- 955
- Registration Number
- NCT01998438
- Locations
- 🇨🇳
Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC, Beijing, Beijing, China
TXA Study in Major Oncologic Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-11-08
- Last Posted Date
- 2023-08-07
- Lead Sponsor
- Spectrum Health Hospitals
- Target Recruit Count
- 76
- Registration Number
- NCT01980355
- Locations
- 🇺🇸
Spectrum Health Hospitals, Grand Rapids, Michigan, United States
The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain
- Conditions
- Interventions
- First Posted Date
- 2013-10-17
- Last Posted Date
- 2019-05-17
- Lead Sponsor
- St. Olavs Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT01964781
- Locations
- 🇳🇴
St Olavs University Hospital, Trondheim, Norway
The Effect of Tranexamic Acid on Transfusion Rates in Intertrochanteric Hip Fractures
- First Posted Date
- 2013-09-12
- Last Posted Date
- 2017-03-28
- Lead Sponsor
- Hospital for Special Surgery, New York
- Registration Number
- NCT01940536
- Locations
- 🇺🇸
New York Presbyterian Hospital, New York, New York, United States
Testing of the Drug Tranexamic Acids as Prophylaxis of Bleeding in Benign Surgical Removal of the Uterus
- Conditions
- Interventions
- First Posted Date
- 2013-09-12
- Last Posted Date
- 2015-10-22
- Lead Sponsor
- Hillerod Hospital, Denmark
- Target Recruit Count
- 332
- Registration Number
- NCT01940419
- Locations
- 🇩🇰
Department of gynecology and obstetrics, Nordsjællands Hospital, Hillerød, Denmark
The Role of Tranexamic Acid in Reducing Blood Transfusion Requirements After Cardiopulmonary Bypass in Neonates
- Conditions
- Interventions
- First Posted Date
- 2013-08-02
- Last Posted Date
- 2017-02-01
- Lead Sponsor
- Aymen N Naguib
- Registration Number
- NCT01914211
- Locations
- 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States
Mechanism and Early Intervention Research on ALI During Emergence Surgery of Acute Stanford A Aortic Dissection
- Conditions
- Interventions
- First Posted Date
- 2013-07-10
- Last Posted Date
- 2014-01-24
- Lead Sponsor
- Beijing Anzhen Hospital
- Target Recruit Count
- 220
- Registration Number
- NCT01894334
Drug Development Updates
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