Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
World Maternal Antifibrinolytic Trial
- Conditions
- Interventions
- First Posted Date
- 2009-03-31
- Last Posted Date
- 2018-02-26
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 20060
- Registration Number
- NCT00872469
- Locations
- 🇳🇬
University College Hospital, Ibadan, Nigeria
Dose-ranging Study of Two Doses of Tranexamic Acid During Cardiac Surgery
- First Posted Date
- 2008-12-17
- Last Posted Date
- 2016-09-23
- Lead Sponsor
- Hopital Foch
- Target Recruit Count
- 600
- Registration Number
- NCT00809393
- Locations
- 🇫🇷
department of anesthesiology, Bichat Hospital, Paris, France
🇫🇷department of anaesthesiology, CHU Jean Minjoz, Besancon, France
🇫🇷Hopital Foch, Suresnes, France
Tranexamic Acid for Preventing Progressive Intracranial Haemorrhage in Traumatic Brain Injury
- First Posted Date
- 2008-09-18
- Last Posted Date
- 2013-11-25
- Lead Sponsor
- Khon Kaen University
- Target Recruit Count
- 238
- Registration Number
- NCT00755209
- Locations
- 🇹🇭
Khon Kaen Regional hospital, Muang district, Khon Kaen, Thailand
Tranexamic Acid in Surgery of Advanced Ovarian Cancer
- First Posted Date
- 2008-08-22
- Last Posted Date
- 2022-03-15
- Lead Sponsor
- Preben Kjolhede, MD, professor
- Target Recruit Count
- 100
- Registration Number
- NCT00740116
- Locations
- 🇸🇪
Department of Obstetrics and Gynecology, Kalmar Central Hospital, Kalmar, Sweden
🇸🇪Dept of Obstetric and Gynecology, Ryhov Central Hospital, Jönköping, Sweden
🇸🇪University Hospital, Department of Obsterics and Gynecology,, Linköping, Sweden
Tranexamic Acid for Craniofacial Surgery
- First Posted Date
- 2008-07-25
- Last Posted Date
- 2017-02-15
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 20
- Registration Number
- NCT00722436
- Locations
- 🇺🇸
The Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery
- First Posted Date
- 2008-05-05
- Last Posted Date
- 2010-09-03
- Lead Sponsor
- University of Calgary
- Target Recruit Count
- 74
- Registration Number
- NCT00671281
- Locations
- 🇨🇦
Rockyview General Hospital, Calgary, Alberta, Canada
Tranexamic Acid in Urologic Surgery
- First Posted Date
- 2008-05-01
- Last Posted Date
- 2014-04-07
- Lead Sponsor
- Università Vita-Salute San Raffaele
- Registration Number
- NCT00670345
- Locations
- 🇮🇹
Università Vita-Salute San Raffaele, Milano, Italia e Istituto Scientifico San Raffaele, Milano, Italia, Milano, Italy
A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery
- First Posted Date
- 2008-01-08
- Last Posted Date
- 2009-11-10
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 20
- Registration Number
- NCT00588133
Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema (HAE)
- Conditions
- Interventions
- First Posted Date
- 2007-07-13
- Last Posted Date
- 2021-06-09
- Lead Sponsor
- Shire
- Target Recruit Count
- 85
- Registration Number
- NCT00500656
- Locations
- 🇮🇹
Università degli Studi di Milano, Dipartimento di Medicina Interna, Milano, Italy
Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery
- First Posted Date
- 2007-03-07
- Last Posted Date
- 2007-11-30
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 151
- Registration Number
- NCT00444470
- Locations
- 🇨🇦
Trillium Health Centre, Mississauga, Ontario, Canada
🇨🇦Department of Anesthesia and Orthopedics; Toronto Western Hospital, Toronto, Ontario, Canada
🇨🇦St. Michael's Hospital, Toronto, Ontario, Canada
Drug Development Updates
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