Hydrogen

Generic Name: Hydrogen

Drug Type: Small Molecule

Chemical Formula: H_₂

CAS Number: 1333-74-0

Unique Ingredient Identifier: 7YNJ3PO35Z

Background: Hydrogen is under investigation in clinical trial NCT02830854 (Molecular Hydrogen for Cognitive Function and Performance in Elderly).

Clinical Trials

Effect H2 Water on QoL of Patients Receiving Radiotherapy for High Grade Gliomas.

Phase 2

Active, not recruiting

Conditions: Malignant Glioma

Interventions: Drug: Placebo oral tablet
Drug: Hydrogen

First Posted Date: 2019-11-25

Last Posted Date: 2025-05-02

Lead Sponsor: Stony Brook University

Target Recruit Count: 15

Registration Number: NCT04175301

Locations: 🇺🇸
Stony Brook University Medical Center, Stony Brook, New York, United States

Safety of Inhaled Hydrogen Gas Mixtures in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Hydrogen

First Posted Date: 2019-08-06

Last Posted Date: 2021-05-06

Lead Sponsor: Boston Children's Hospital

Target Recruit Count: 8

Registration Number: NCT04046211

Locations: 🇺🇸
Boston Children's Hospital, Boston, Massachusetts, United States

Clinical Trial to Evaluate the Safety and Tolerability of Hydrogen in Patients With Parkinson's Disease

Phase 2

Terminated

Conditions: Parkinson Disease

Interventions: Drug: Hydrogen
Drug: Placebo oral tablet

First Posted Date: 2019-06-03

Last Posted Date: 2023-04-12

Lead Sponsor: Stony Brook University

Target Recruit Count: 2

Registration Number: NCT03971617

Locations: 🇺🇸
Stony Brook University Medical Center, Stony Brook, New York, United States

Effect of Antibiotics on Penile Microbiome and HIV Susceptibility Study in Ugandan Men

Not Applicable

Conditions: Foreskin HIV Susceptibility

Interventions: Drug: Oral Tinidazole
Drug: Topical metronidazole
Drug: Topical Clindamycin
Drug: Topical Hydrogen Peroxide

First Posted Date: 2018-01-26

Last Posted Date: 2018-01-26

Lead Sponsor: University of Toronto

Target Recruit Count: 125

Registration Number: NCT03412071

Locations: 🇺🇬
UVRI-IAVI HIV Vaccine Program, Entebbe, Wakiso, Uganda

Neuroprotection in Acute Ischemic Stroke

Phase 2

Completed

Conditions: Stroke, Ischemic

Interventions: Drug: Hydrogen
Other: Placebo Hydrogen
Other: Placebo Minocycline
Drug: Minocycline

First Posted Date: 2017-10-24

Last Posted Date: 2023-12-19

Lead Sponsor: Stony Brook University

Target Recruit Count: 15

Registration Number: NCT03320018

Locations: 🇺🇸
Stony Brook University Hospital, Stony Brook, New York, United States

Adjunctive Hydrogen Peroxide for Periodontal Therapy

Phase 4

Terminated

Conditions: Periodontitis, Chronic

Interventions: Drug: Hydrogen Peroxide Gel, 13 weeks
Drug: Hydrogen Peroxide Gel, 26 weeks
Other: Scaling and Root planing group

First Posted Date: 2017-08-25

Last Posted Date: 2022-12-21

Lead Sponsor: Loma Linda University

Target Recruit Count: 42

Registration Number: NCT03262701

Locations: 🇺🇸
Loma Linda University Health, Loma Linda, California, United States

Effectiveness of Office Bleaching Agents in Patients of Different Age Group

Not Applicable

Completed

Conditions: Satisfaction

Interventions: Drug: Hydrogen peroxide 35%
Drug: Hydrogen peroxide 38%

First Posted Date: 2017-06-22

Last Posted Date: 2018-02-13

Lead Sponsor: Federal University of Uberlandia

Target Recruit Count: 56

Registration Number: NCT03194984

Locations: 🇧🇷
Gisele Rodrigues da Silva, Uberlândia, Av Pará S/n Bloco 4 L Anexo A Sala 42 Campus Umuarama, Brazil

IN-OFFICE TOOTH BLEACHING WITH 37% CARBAMIDE PEROXIDE

Phase 3

Completed

Conditions: Tooth Sensitivity

Interventions: Drug: 37% Carbamide Peroxide
Drug: 35% hydrogen Peroxide

First Posted Date: 2016-10-17

Last Posted Date: 2016-11-15

Lead Sponsor: Universidade Federal de Sergipe

Target Recruit Count: 50

Registration Number: NCT02935114

Therapeutic Effects of Hydrogen on Steroid-refractory/or Steroid-dependent cGVHD

Phase 2

Recruiting

Conditions: Chronic Graft-versus-host Disease

Interventions: Drug: Hydrogen

First Posted Date: 2016-09-28

Last Posted Date: 2020-07-21

Lead Sponsor: Navy General Hospital, Beijing

Target Recruit Count: 21

Registration Number: NCT02918188

Locations: 🇨🇳
Navy General Hospital, Beijing, Beijing, China

In-office and At-home Tooth Bleaching Using Low Concentration Peroxides.

Not Applicable

Completed

Conditions: Discolored Teeth

Interventions: Drug: hydrogen peroxide 6%
Drug: hydrogen peroxide 15%
Drug: Carbamide Peroxide 10%

First Posted Date: 2016-06-28

Last Posted Date: 2018-02-12

Lead Sponsor: Federal University of Minas Gerais

Target Recruit Count: 90

Registration Number: NCT02816593

Locations: 🇧🇷
Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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