Methocarbamol

Generic Name: Methocarbamol

Brand Names: Robaxacet, Robaxacet-8, Robaxin, Robaxisal

Drug Type: Small Molecule

Chemical Formula: C_₁₁H_₁₅NO_₅

CAS Number: 532-03-6

Unique Ingredient Identifier: 125OD7737X

Background: Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain. It is a guaiacol glyceryl ether.

Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose that may be combined with acetaminophen or ibuprofen. A combination product with acetylsalicylic acid and codeine is available in Canada by prescription.

Methocarbamol was FDA approved on 16 July 1957.

Indication: Methocarbamol tablets and intramuscular injections are indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. Oral methocarbamol in America may be given up to 1500mg 4 times daily for 2-3 days.

In Canada, methocarbamol containing oral formulations are sold over the counter for pain associated with muscle spasm. However, if these combination formulations include codeine, they are prescription only.

Associated Conditions: Discomfort, Gout, Muscle Spasms, Myalgia, Pain, Rheumatism, Tetanus, Articular inflammation

Clinical Trials

A Phase 3 Study of F14 for Management of Pain Following Total Knee Replacement

Phase 3

Active, not recruiting

Conditions: Post Operative Pain

Interventions: Drug: F14
Drug: 0.25 % Bupivacaine HCl
Drug: Acetaminophen
Drug: Methocarbamol

First Posted Date: 2022-11-03

Last Posted Date: 2024-01-31

Lead Sponsor: Arthritis Innovation Corporation

Target Recruit Count: 151

Registration Number: NCT05603832

Locations: 🇺🇸
Woodland International Research Group, Little Rock, Arkansas, United States
🇺🇸
HD Research - Legent Orthopedic Hospital, Carrollton, Texas, United States
🇺🇸
Phoenix Clinical Research, Tamarac, Florida, United States

and more 4 locations

Methocarbamol in Ventral and Inguinal HR

Phase 4

Active, not recruiting

Conditions: Inguinal Hernia
Ventral Hernia

Interventions: Drug: Methocarbamol
Drug: Standard Opioid
Drug: Standard opioid plus methocarbamol

First Posted Date: 2022-05-24

Last Posted Date: 2025-05-02

Lead Sponsor: Prisma Health-Upstate

Target Recruit Count: 164

Registration Number: NCT05388929

Locations: 🇺🇸
Prisma Health, Greenville, South Carolina, United States

Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure

Not Applicable

Recruiting

Conditions: Nephrolithiasis
Urolithiasis
Kidney Diseases
Ureteral Diseases
Kidney Calculi
Ureteral Calculi

Interventions: Drug: Methocarbamol
Drug: Oxybutynin

First Posted Date: 2021-10-29

Last Posted Date: 2025-04-25

Lead Sponsor: Northwestern University

Target Recruit Count: 126

Registration Number: NCT05100017

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States

Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures

Phase 4

Recruiting

Conditions: Hip Arthroscopy

Interventions: Drug: Ibuprofen
Drug: Oxycodone
Drug: Gabapentin
Drug: Acetaminophen
Drug: Methocarbamol

First Posted Date: 2021-10-13

Last Posted Date: 2024-06-18

Lead Sponsor: Mayo Clinic

Target Recruit Count: 188

Registration Number: NCT05076110

Locations: 🇺🇸
Mayo clinic, Rochester, Minnesota, United States

Japanese IP-TN Trial

Phase 3

Completed

Conditions: Pain

Interventions: Drug: Loxoprofen sodium
Drug: Methocarbamol

First Posted Date: 2016-07-13

Last Posted Date: 2018-07-20

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 80

Registration Number: NCT02831569

Locations: 🇯🇵
Shinjuku Res. Park Clinic, Tokyo, I.M., Tokyo, Shinjyuku-ku, Japan
🇯🇵
Fukuwa Clinic, Tokyo, Chuo-ku, Japan
🇯🇵
Tokyo-Eki Center-building Clinic, Tokyo, Chuo-ku, Japan