Flumazenil
- Generic Name
- Flumazenil
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C15H14FN3O3
- CAS Number
- 78755-81-4
- Unique Ingredient Identifier
- 40P7XK9392
- Background
Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.
- Indication
For the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Also for the management of benzodiazepine overdose as an adjunct for appropriate support...
- Associated Conditions
- Sedation caused by benzodiazepine
- Associated Therapies
- Anesthesia, Reversal, Reversal of sedation therapy
Flumazenil Reversal of Oral Triazolam
- First Posted Date
- 2008-06-12
- Last Posted Date
- 2008-06-12
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 14
- Registration Number
- NCT00695630
- Locations
- 🇺🇸
Dental Fears Research Clinic, Seattle, Washington, United States
Rapid Benzodiazepine Detoxification Using Flumazenil - 1
- Conditions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2016-09-08
- Lead Sponsor
- Yale University
- Target Recruit Count
- 10
- Registration Number
- NCT00000246
- Locations
- 🇺🇸
Yale University, Psychiatry, New Haven, Connecticut, United States
Drug Development Updates
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