MedPath

Acyclovir

Generic Name
Acyclovir
Brand Names
Sitavig, Xerese, Zovirax
Drug Type
Small Molecule
Chemical Formula
C8H11N5O3
CAS Number
59277-89-3
Unique Ingredient Identifier
X4HES1O11F

Overview

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.

Background

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.

Indication

An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older. Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox. An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients. An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older. An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis. An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.

Associated Conditions

  • Bell's Palsy
  • Chickenpox
  • Cytomegalovirus (CMV) Infections
  • Herpes Simplex Infections
  • Herpes Zoster
  • Herpes simplex encephalitis
  • Herpes simplex of the oral-labial
  • Herpes simplex type I reactivation
  • Recurrent Genital Herpes (RGH)
  • Recurrent Herpes Labialis
  • VZV re-activation
  • Acute Genital herpes
  • Acute Herpes labialis
  • Acute Herpetic keratitis
  • Severe Genital herpes

FDA Approved Products

acyclovir
Manufacturer:RedPharm Drug
Route:ORAL
Strength:400 mg in 1 1
Approved: 2023/02/02
NDC:67296-1707
Acyclovir
Manufacturer:Modavar Pharmaceuticals LLC
Route:ORAL
Strength:200 mg in 1 1
Approved: 2023/03/02
NDC:72241-028
Acyclovir
Manufacturer:NuCare Pharmaceuticals,Inc.
Route:ORAL
Strength:400 mg in 1 1
Approved: 2023/12/01
NDC:68071-4799
ACYCLOVIR
Manufacturer:NuCare Pharmaceuticals,Inc.
Route:ORAL
Strength:400 mg in 1 1
Approved: 2022/01/14
NDC:68071-2279
acyclovir
Manufacturer:Slate Run Pharmaceuticals, LLC
Route:INTRAVENOUS
Strength:50 mg in 1 mL
Approved: 2024/02/29
NDC:70436-030

Singapore Approved Products

VILERM TABLET 200 mg
Manufacturer:SIAM BHEASACH CO LTD
Form:TABLET
Strength:200 mg
Online:Yes
Approved: 1997/07/16
Approval:SIN09451P
AVORAX CREAM 5%
Manufacturer:XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD
Form:CREAM
Strength:5% w/w
Online:Yes
Approved: 1997/03/18
Approval:SIN09254P
DBL ACICLOVIR INTRAVENOUS INFUSION 250mg/10ml
Manufacturer:HOSPIRA AUSTRALIA PTY LTD
Form:INJECTION
Strength:250mg
Online:Yes
Approved: 1997/06/13
Approval:SIN09367P
VIRLESS TABLET 800 mg
Manufacturer:Y S P INDUSTRIES (M) SDN BHD
Form:TABLET
Strength:800 mg
Online:Yes
Approved: 1998/09/29
Approval:SIN10084P
LOVIR TABLETS 400 mg
Manufacturer:RANBAXY (MALAYSIA) SDN BHD
Form:TABLET
Strength:400 mg
Online:Yes
Approved: 1998/02/12
Approval:SIN09629P

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