Topical Ganciclovir Versus Systemic Aciclovir in the Treatment of Herpetic Keratitis

Not Applicable

Completed

• Conditions: Herpetic Keratitis
• Interventions: Drug: Ganciclovir (GCV); Drug: Acyclovir 400 MG

• Registration Number: NCT06757907
• Lead Sponsor: Al-Azhar University

Brief Summary

Traditional antiviral treatments, including systemic acyclovir, have shown effectiveness in resolving keratitis but can also lead to complications, including ocular surface toxicity and the development of acyclovir-resistant strains of HSV. Topical ganciclovir 0.15% ophthalmic gel presents a safer alternative for managing herpetic keratitis, offering effective viral suppression with minimal toxicity. This study aims to compare the efficacy and safety of topical ganciclovir versus systemic acyclovir in treating herpetic keratitis, providing valuable insights into optimal management strategies for this condition

Detailed Description

Not available

Study Timeline

• Study Start: 2024-10-01
• Status Verified: 2024-12
• Primary Completion: 2024-12-20
• Study Completion: 2024-12-25
• Study First Submitted: 2024-12-27
• Study First Submitted QC: 2024-12-27
• Last Update Submitted: 2024-12-27
• Study First Posted: 2025-01-03
• Last Update Posted: 2025-01-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients diagnosed with herpetic keratitis

Exclusion Criteria

• Patients with known allergies to ganciclovir or acyclovir
• Severe ocular surface disease
• Those who have previously received antiviral therapy for herpetic keratitis within the last month

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ganciclovir	Ganciclovir (GCV)	-
Systemic acyclovir	Acyclovir 400 MG	-

Primary Outcome Measures

Name	Time	Method
Corneal healing	At 4 and 6 weeks	Heling of the keratitis

Secondary Outcome Measures

Name	Time	Method
Sie effects	at 4 and 6 weeks	Measuring the percentage of the side effects of the drugs

Trial Locations

Locations (1)

Al-Azhar university; 🇪🇬 Damietta, Egypt