Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis

• Conditions: Anterior Uveitis

• Registration Number: NCT01486693
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The purpose of this study was to evaluate long term efficacy and safety of topical ganciclovir treatment in Cytomegalovirus (CMV) anterior uveitis.

Detailed Description

The investigators will enroll 60 patients with positive results of the CMV PCR (polymerase chain reaction) from aqueous humor tapping from January 2006 to June 2011. All the patients (40 men, 20 women) were immunocompetent and diagnosed as symptomatic CMV infection. Their medical records will be reviewed, including demographic data as well as their ophthalmic and medical histories.

The purpose of this study was to evaluate long term efficacy and safety of topical ganciclovir treatment in CMV anterior uveitis.

Study Timeline

• Study Start: 2011-10
• Study First Submitted: 2011-11-16
• Status Verified: 2011-12
• Primary Completion: 2011-12
• Study First Submitted QC: 2011-12-05
• Last Update Submitted: 2011-12-05
• Study First Posted: 2011-12-06
• Last Update Posted: 2011-12-06
• Study Completion: 2012-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients with positive results of the CMV PCR (polymerase chain reaction) from aqueous humor tapping. All the patients were immunocompetent and diagnosed as symptomatic CMV infection.

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Exclusion Criteria

• Patients without positive results of the CMV PCR
• Immunocompromised patients with positive results of the CMV PCR

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Anterior chamber inflammation	4 weeks after starting treatment	anterior chamber cell grading based on slit lamp microscopy

Secondary Outcome Measures

Name	Time	Method
probability of relapse-free	2 years after treatment	Kaplan-Meier curve of relapse-free probability

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan