Metoprolol
- Generic Name
- Metoprolol
- Brand Names
- Kapspargo, Lopressor, Lopressor Hct, Toprol
- Drug Type
- Small Molecule
- Chemical Formula
- C15H25NO3
- CAS Number
- 51384-51-1
- Unique Ingredient Identifier
- GEB06NHM23
- Background
Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release. The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative. To this date, it is one of the preferre...
- Indication
Metoprolol is indicated for the treatment of angina, heart failure, myocardial infarction, atrial fibrillation, atrial flutter and hypertension.
Some off-label uses of metoprolol include supraventricular tachycardia and thyroid storm.
...
- Associated Conditions
- Angina Pectoris, Atrial Fibrillation, Hypertension, Migraine, Myocardial Infarction, Supraventricular Tachycardia (SVT), Thyroid Crisis, Chronic heart failure with reduced ejection fraction (NYHA Class II), Chronic heart failure with reduced ejection fraction (NYHA Class III)
- Associated Therapies
- -
Beta-blockers to Patients With Chronic Obstructive Pulmonary Disease
- Conditions
- Interventions
- First Posted Date
- 2018-06-25
- Last Posted Date
- 2024-11-15
- Lead Sponsor
- Ole Frobert, MD, PhD
- Target Recruit Count
- 1700
- Registration Number
- NCT03566667
- Locations
- 🇸🇪
University Hospital of Örebro, Örebro, Sweden
Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4
- Conditions
- Interventions
- First Posted Date
- 2018-06-14
- Last Posted Date
- 2024-10-26
- Lead Sponsor
- LEO Pharma
- Target Recruit Count
- 40
- Registration Number
- NCT03556592
- Locations
- 🇳🇱
LEO Pharma Investigational Site, Leiden, Netherlands
Bariatric Surgery and Pharmacokinetics of Metoprolol
- Conditions
- First Posted Date
- 2018-05-09
- Last Posted Date
- 2023-06-01
- Lead Sponsor
- Norwegian University of Science and Technology
- Target Recruit Count
- 12
- Registration Number
- NCT03519906
- Locations
- 🇳🇴
St. Olavs University Hospital, Trondheim, Norway
Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s
- Conditions
- Interventions
- First Posted Date
- 2018-03-07
- Last Posted Date
- 2018-05-17
- Lead Sponsor
- Corcept Therapeutics
- Target Recruit Count
- 27
- Registration Number
- NCT03457597
- Locations
- 🇺🇸
Celerion, Tempe, Arizona, United States
A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With Ticagrelor
- Conditions
- Interventions
- First Posted Date
- 2018-02-22
- Last Posted Date
- 2018-05-11
- Lead Sponsor
- Vastra Gotaland Region
- Target Recruit Count
- 10
- Registration Number
- NCT03441412
- Locations
- 🇸🇪
gothia Forum CTC, Gothenburg, Sweden
A Multi-Center Study on the Metoprolol Optimal Dosing Pathway of Metoprolol Application in Chinese Patients With Acute Coronary Syndrome
- First Posted Date
- 2018-01-29
- Last Posted Date
- 2019-07-19
- Lead Sponsor
- Yun Dai Chen
- Target Recruit Count
- 1000
- Registration Number
- NCT03413410
- Locations
- 🇨🇳
The General Hospital of PLA, Beijing, China
Metoprolol to Reduce Perioperative Myocardial Injury
- First Posted Date
- 2017-05-03
- Last Posted Date
- 2023-10-23
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 170
- Registration Number
- NCT03138603
- Locations
- 🇺🇸
University of Chicago Medicine, Chicago, Illinois, United States
🇺🇸Washington University School of Medicine, Saint Louis, Missouri, United States
A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2017-04-06
- Last Posted Date
- 2017-08-10
- Lead Sponsor
- Swedish Orphan Biovitrum
- Target Recruit Count
- 36
- Registration Number
- NCT03103568
- Locations
- 🇩🇪
PAREXEL EPCU Berlin, Berlin, Germany
A Drug to Drug Interaction Study of Sotagliflozin With Midazolam and Metoprolol
- Conditions
- Interventions
- First Posted Date
- 2016-10-20
- Last Posted Date
- 2022-04-25
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 24
- Registration Number
- NCT02940379
- Locations
- 🇺🇸
Investigational Site Number 840001, Knoxville, Tennessee, United States
Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.
- First Posted Date
- 2016-10-05
- Last Posted Date
- 2017-04-12
- Lead Sponsor
- Mikkel Bring Christensen
- Target Recruit Count
- 10
- Registration Number
- NCT02924454
- Locations
- 🇩🇰
Bispebjerg University Hospital Copenhagen, Copenhagen NW, Capital Region of Denmark, Denmark
Drug Development Updates
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