Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Excision of Primary Liver Tumors

Phase 4

Recruiting

Conditions: Hepatocellular Carcinoma

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2022-04-18

Last Posted Date: 2022-11-30

Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Target Recruit Count: 500

Registration Number: NCT05331911

Locations: 🇨🇳
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan

Ultrasound-guided Paravertebral Block Versus Mid-point Transverse Process Pleura Block in Mastectomy Surgery

Phase 4

Completed

Conditions: Anesthesia, Local
Surgery
Mastectomy; Lymphedema

Interventions: Drug: bupivacaine
Device: 22 gauge 100 mm needle
Drug: Propofol
Drug: fentanyl

First Posted Date: 2022-04-18

Last Posted Date: 2022-04-18

Lead Sponsor: Ataturk University

Target Recruit Count: 64

Registration Number: NCT05332028

Locations: 🇹🇷
Mehmet Aksoy, Erzurum, string:Turkey, Turkey

Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)

Phase 3

Active, not recruiting

Conditions: Sedation

Interventions: Drug: Propofol
Drug: Isoflurane

First Posted Date: 2022-04-14

Last Posted Date: 2024-06-06

Lead Sponsor: Sedana Medical

Target Recruit Count: 235

Registration Number: NCT05327296

Locations: 🇺🇸
Memorial Health Services, Long Beach, California, United States
🇺🇸
University of Miami, Coral Gables, Florida, United States
🇺🇸
The New York and Presbyterian Hospital, New York, New York, United States

and more 13 locations

Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders

Phase 4

Conditions: Sleep Disorder

Interventions: Drug: Saline
Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2022-04-13

Last Posted Date: 2022-10-03

Lead Sponsor: Xiangya Hospital of Central South University

Target Recruit Count: 321

Registration Number: NCT05325762

Locations: 🇨🇳
Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
🇨🇳
West China Hospital, Sichuan University, Chengdu, Sichuan, China

and more 1 locations

Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)

Phase 3

Active, not recruiting

Conditions: Sedation

Interventions: Drug: Propofol
Drug: Isoflurane

First Posted Date: 2022-04-05

Last Posted Date: 2024-05-03

Lead Sponsor: Sedana Medical

Target Recruit Count: 235

Registration Number: NCT05312385

Locations: 🇺🇸
Emory University, Atlanta, Georgia, United States
🇺🇸
The Cleveland Clinic Foundation, Cleveland, Ohio, United States
🇺🇸
University of Virginia, Charlottesville, Virginia, United States

and more 11 locations