Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Heart Rate Variability Under Propofol and Sevoflurane

Not Applicable

Completed

Conditions: General Anesthesia

Interventions: Drug: Sevoflurane
Drug: Propofol
Drug: Remifentanil

First Posted Date: 2017-04-04

Last Posted Date: 2017-04-04

Lead Sponsor: Hôpital Armand Trousseau

Target Recruit Count: 40

Registration Number: NCT03098875

Locations: 🇫🇷
Departement d'anesthesie Hopital Armand Trousseau, Paris, France

Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy

Phase 4

Completed

Conditions: Obstructive Sleep Apnea of Adult

Interventions: Drug: Propofol
Drug: Dexmedetomidine

First Posted Date: 2017-03-27

Last Posted Date: 2018-04-13

Lead Sponsor: Essam Fathi

Target Recruit Count: 50

Registration Number: NCT03091894

Locations: 🇪🇬
Zagazig university, Zagazig, Sharkia, Egypt

Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients

Not Applicable

Completed

Conditions: Peripheral Solitary Pulmonary Nodule or Tuberculoma

Interventions: Drug: Propofol
Drug: Sulfentanyl
Drug: Dexmedetomidine
Drug: Lidocaine
Drug: Ropivacaine

First Posted Date: 2017-03-22

Last Posted Date: 2020-05-07

Lead Sponsor: Shenzhen Third People's Hospital

Target Recruit Count: 48

Registration Number: NCT03086213

Locations: 🇨🇳
the Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China

Design of a Closed-loop Controller Based on the Bispectral Index (BIS) Effectiveness of the Smith Predictor

Not Applicable

Conditions: General Anesthesia

Interventions: Drug: Propofol

First Posted Date: 2017-03-08

Last Posted Date: 2017-03-08

Lead Sponsor: José Antonio Reboso Morales

Target Recruit Count: 50

Registration Number: NCT03073408

Locations: 🇪🇸
Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain

Randomised Controlled Study of Popofol Versus Midazolam as Sedation in Endoscopy With Advanced Liver Disease.

Phase 4

Conditions: Liver Diseases

Interventions: Drug: Midazolam
Drug: Propofol
Drug: Fentanyl

First Posted Date: 2017-02-24

Last Posted Date: 2017-04-27

Lead Sponsor: Sherief Abd-Elsalam

Target Recruit Count: 100

Registration Number: NCT03063866

Locations: 🇪🇬
Sherief Abd-Elsalam, Cairo, Egypt

Effect of Total Intravenous Anaesthesia With Propofol on Postoperative Pain After Bilateral Third Molar Surgery

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Sevoflurane
Drug: propofol

First Posted Date: 2017-02-20

Last Posted Date: 2020-07-07

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 96

Registration Number: NCT03058341

Locations: 🇭🇰
The University of Hong Kong, Hong Kong, Hong Kong

Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects

Withdrawn

Conditions: Postoperative Pain

Interventions: Procedure: general anaesthesia
Drug: Propofol

First Posted Date: 2017-02-20

Last Posted Date: 2022-10-13

Lead Sponsor: The University of Hong Kong

Registration Number: NCT03058354

Locations: 🇭🇰
The University of Hong Kong, Hong Kong, Hong Kong

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Not Applicable

Conditions: Hernia, Inguinal
Pain, Postoperative

Interventions: Procedure: Caudal-epidural nerve block
Procedure: Ilioinguinal/iliohypogastric nerve block
Drug: Acetaminophen
Drug: Sevoflurane
Drug: Remifentanil
Drug: Propofol
Drug: Morphine
Drug: Ondansetron
Drug: Dexamethasone
Drug: Ketorolac

First Posted Date: 2017-02-03

Last Posted Date: 2017-11-14

Lead Sponsor: Alberta Children's Hospital

Target Recruit Count: 88

Registration Number: NCT03041948

Locations: 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada
🇨🇦
Royal University Hospital/University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair

Not Applicable

Completed

Conditions: Pain, Postoperative
Testicle Undescended

Interventions: Procedure: Caudal-epidural nerve block
Procedure: Ilioinguinal/iliohypogastric nerve block
Drug: Acetaminophen
Drug: Sevoflurane
Drug: Remifentanil
Drug: Propofol
Drug: Morphine
Drug: Ondansetron
Drug: Dexamethasone
Drug: Ketorolac
Drug: Ropivacaine

First Posted Date: 2017-02-03

Last Posted Date: 2022-02-16

Lead Sponsor: Alberta Children's Hospital

Target Recruit Count: 90

Registration Number: NCT03041935

Locations: 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada

General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial

Phase 4

Active, not recruiting

Conditions: Anesthesia, General
Surgical Oncology

Interventions: Drug: Propofol
Drug: Volatile Agent

First Posted Date: 2017-01-27

Last Posted Date: 2024-03-13

Lead Sponsor: Stony Brook University

Target Recruit Count: 1804

Registration Number: NCT03034096

Locations: 🇺🇸
Stony Brook University Hospital, Stony Brook, New York, United States
🇺🇸
University of Rochester Medical Center, Rochester, New York, United States
🇺🇸
Roswell Park Cancer Center, Buffalo, New York, United States

and more 2 locations

Drug Development Updates

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