Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

A Low Dose Dexmedetomidine in Sedation Colonoscopy

Not Applicable

Not yet recruiting

Conditions: Colonoscopy

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2024-01-17

Last Posted Date: 2024-01-17

Lead Sponsor: West China Hospital

Target Recruit Count: 104

Registration Number: NCT06208956

The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

Not Applicable

Recruiting

Conditions: Mechanical Ventilation Complication
Respiratory Failure
Critical Illness
Lung Injury
Respiratory Distress Syndrome, Adult

Interventions: Procedure: Titrating sedation targeting both optimal P0.1 and appropriate arousal level
Drug: Fentanyl
Drug: Midazolam
Drug: Propofol
Drug: Dexmedetomidine
Drug: Cisatracurium

First Posted Date: 2024-01-12

Last Posted Date: 2025-05-22

Lead Sponsor: Siriraj Hospital

Target Recruit Count: 214

Registration Number: NCT06203405

Locations: 🇹🇭
Siriraj Hospital, Bangkok, Thailand

The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients

Not Applicable

Recruiting

Conditions: Hysteroscopy
Overweight or Obesity
Hypoxia

Interventions: Drug: remimazolam
Drug: Propofol

First Posted Date: 2024-01-03

Last Posted Date: 2024-07-23

Lead Sponsor: RenJi Hospital

Target Recruit Count: 600

Registration Number: NCT06187896

Locations: 🇨🇳
Diansan Su, Shanghai, Shanghai, China

Propofol for Prophylaxis of Morphine Induced Pruritis in Caesarean Section

Phase 3

Not yet recruiting

Conditions: Pruritus Caused by Drug

Interventions: Drug: Propofol

First Posted Date: 2024-01-03

Last Posted Date: 2024-01-03

Lead Sponsor: Assiut University

Target Recruit Count: 200

Registration Number: NCT06188546

Effect of Remimazolam on Postoperative Delirium

Not Applicable

Recruiting

Conditions: General Anesthetic Drug Adverse Reaction

Interventions: Drug: remimazolam
Drug: propofol

First Posted Date: 2023-12-26

Last Posted Date: 2023-12-26

Lead Sponsor: Zhihong LU

Target Recruit Count: 190

Registration Number: NCT06180876

Locations: 🇨🇳
Xijing hospital, Fourth military medical university, Xi'an, Shaanxi, China

EEG-fMRI Experiments During Anesthesia Induction With Propofol

Not Applicable

Recruiting

Conditions: Anesthesia

Interventions: Drug: Propofol
Behavioral: visual flickering stimulation at the alpha frequency

First Posted Date: 2023-12-22

Last Posted Date: 2023-12-22

Lead Sponsor: Technical University of Munich

Target Recruit Count: 35

Registration Number: NCT06179719

Locations: 🇩🇪
Klinikum rechts der Isar - Klinik für Anästhesiologie und Intensivmedizin, Munich, Bavaria, Germany
🇩🇪
Technische Universität München, München, München (Stadt), Germany