Alpelisib

Generic Name
Alpelisib
Brand Names
Piqray 300 Mg Daily Dose, Vijoice 50 Mg 28 Day, Piqray
Drug Type
Small Molecule
Chemical Formula
C19H22F3N5O2S
CAS Number
1217486-61-7
Unique Ingredient Identifier
08W5N2C97Q
Background

Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target thi...

Indication

Alpelisib is indicated in combination with fulvestrant to treat postmenopausal women, and men, with advanced or metastatic breast cancer. This cancer must be hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, and PIK3CA­ mutated. The cancer must be detected by an FDA-approved test following progression on or after an en...

Associated Conditions
HR+, HER2-, Advanced Breast Cancer, PIK3CA-Related Overgrowth Spectrum (PROS), Metastatic HR + HER2 - breast cancer
Associated Therapies
-
© Copyright 2024. All Rights Reserved by MedPath