Isosorbide
- Generic Name
- Isosorbide
- Drug Type
- Small Molecule
- Chemical Formula
- C6H10O4
- CAS Number
- 652-67-5
- Unique Ingredient Identifier
- WXR179L51S
- Background
Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the isosorbide mononitrate and isosorbide dinitrate forms, and is used for the prevention of angina. Refer to these drug entries for more information.
- Indication
Isosorbide was previously indicated for temporary reduction of intraocular pressure and used to interrupt an acute glaucoma attack, however, this is not a currently approved indication. Refer to isosorbide mononitrate and isosorbide dinitrate drug entries for more isosorbide indications.
- Associated Conditions
- Angina Pectoris
Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed)
- Conditions
- Hypertension
- Interventions
- First Posted Date
- 2009-03-30
- Last Posted Date
- 2015-07-28
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 64
- Registration Number
- NCT00871871
Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3
- Conditions
- Obesity
- Interventions
- Drug: Control (bradykinin)
- First Posted Date
- 2008-05-29
- Last Posted Date
- 2013-02-25
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 24
- Registration Number
- NCT00685945
- Locations
- 🇺🇸
Vanderbilt University Medical Center-GCRC, Nashville, Tennessee, United States
Drug Development Updates
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