Fexofenadine
- Generic Name
- Fexofenadine
- Brand Names
- Allegra, Allegra-D, Mucinex Non-drowsy Allergy, Wal-fex, Telfast
- Drug Type
- Small Molecule
- Chemical Formula
- C32H39NO4
- CAS Number
- 83799-24-0
- Unique Ingredient Identifier
- E6582LOH6V
- Background
Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamines, such as diphenhydramine, which readily bind to o...
- Indication
In the United States, fexofenadine is indicated for the symptomatic treatment of allergic rhinitis in patients ≥2 years old and chronic idiopathic urticaria in patients ≥6 months old. In Canada, fexofenadine carries the same indications but is approved only for patients ≥12 years old. Fexofenadine is also available in combination with pseudoephedrine for the...
- Associated Conditions
- Allergic Rhinitis (AR), Chronic Idiopathic Urticaria, Seasonal Allergic Rhinitis
- Associated Therapies
- Antihistamine
Study to Evaluate the Pharmacokinetics and Pharmacodynamics of JMI-001
- First Posted Date
- 2017-06-12
- Last Posted Date
- 2017-06-12
- Lead Sponsor
- Sen-Jam Pharmaceutical
- Target Recruit Count
- 48
- Registration Number
- NCT03183297
A Drug Interaction Study Between Danicopan and Midazolam, Fexofenadine, and Mycophenolate Mofetil in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2017-04-11
- Last Posted Date
- 2021-06-24
- Lead Sponsor
- Alexion Pharmaceuticals, Inc.
- Target Recruit Count
- 35
- Registration Number
- NCT03108274
- Locations
- 🇳🇿
Clinical Trial Site, Auckland, New Zealand
The Effect Dialysis on the Pharmacokinetics of Fexofenadine
- First Posted Date
- 2017-03-13
- Last Posted Date
- 2017-11-27
- Lead Sponsor
- Lawson Health Research Institute
- Target Recruit Count
- 30
- Registration Number
- NCT03078777
- Locations
- 🇨🇦
London Health Sciences Centre, London, Ontario, Canada
Oral Pharmacokinetics of Sulfasalazine, Paracetamol, Fexofenadine and Valsartan Using Different Administration Mediums
- First Posted Date
- 2017-01-06
- Last Posted Date
- 2017-01-06
- Lead Sponsor
- University Medicine Greifswald
- Target Recruit Count
- 9
- Registration Number
- NCT03012763
Montelukast and Fexofenadine Versus Montelukast and Levocetrizine Combination in Allergic Rhinitis
- Conditions
- Interventions
- First Posted Date
- 2015-09-16
- Last Posted Date
- 2015-09-16
- Lead Sponsor
- Indira Gandhi Medical College, Shimla
- Target Recruit Count
- 70
- Registration Number
- NCT02551536
Evaluation of the Potential Pharmacokinetic Interactions Between Probe Drugs in the Geneva Phenotyping Cocktail
- Conditions
- Interventions
- First Posted Date
- 2015-03-18
- Last Posted Date
- 2017-02-07
- Lead Sponsor
- Jules Desmeules
- Target Recruit Count
- 30
- Registration Number
- NCT02391688
- Locations
- 🇨🇭
Centre de Recherche Clinique, HUG, Rue Gabrielle Perret-Gentil 4, Genève, Switzerland
An Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Fexofenadine in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-06-06
- Last Posted Date
- 2014-09-08
- Lead Sponsor
- Lexicon Pharmaceuticals
- Target Recruit Count
- 24
- Registration Number
- NCT02157558
- Locations
- 🇺🇸
Lexicon Investigational Site, Dallas, Texas, United States
Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria
- Conditions
- Interventions
- First Posted Date
- 2013-09-12
- Last Posted Date
- 2014-02-19
- Lead Sponsor
- Grupo de Alergología Clínica y Experimental
- Target Recruit Count
- 150
- Registration Number
- NCT01940393
- Locations
- 🇨🇴
Medellin, Medellin, Antioquia, Colombia
Bioequivalence Study of Fexofenadine Hydrochloride Orally Disintegrated Tablets 30 mg Under Fasting Condition
- First Posted Date
- 2013-06-28
- Last Posted Date
- 2013-06-28
- Lead Sponsor
- Dr. Reddy's Laboratories Limited
- Target Recruit Count
- 80
- Registration Number
- NCT01888718
- Locations
- 🇮🇳
Bioserve Clinical Research Private Limited, Balanagar, Hyderabad, Andhra Pradesh, India
Dose Proportionality of Fexofenadine in Healthy Human Egyptian Volunteers
- First Posted Date
- 2013-01-14
- Last Posted Date
- 2013-01-14
- Lead Sponsor
- Damanhour University
- Target Recruit Count
- 25
- Registration Number
- NCT01767272
Drug Development Updates
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