Povidone-iodine
- Generic Name
- Povidone-iodine
- Brand Names
- Betadine, Kenalog, Marbeta, Marcaine, P-Care M, P-Care MG, P-care, P-care X, Summer's Eve Medicated
- Drug Type
- Small Molecule
- CAS Number
- 25655-41-8
- Unique Ingredient Identifier
- 85H0HZU99M
- Background
Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. During in vitro testing to demonstrate anti-bacterial activity it was found that the complex was less toxic in mice than tincture of iodine. Human clinical trials showed the product to be superior to other iodine formulations. Povidone-iodine was immediately marketed, and has since become the universally preferred iodine antiseptic.
- Indication
For topical application in the treatment and prevention of infection in wounds.
- Associated Conditions
- Skin Infections
- Associated Therapies
- Skin disinfection, Antiseptic skin preparation therapy, Irrigation of the ocular surface therapy, Prepping of the periocular region
Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)
- Conditions
- Infection
- Interventions
- First Posted Date
- 2009-05-11
- Last Posted Date
- 2015-08-27
- Lead Sponsor
- Northwell Health
- Registration Number
- NCT00896402
- Locations
- 🇺🇸
Syosset Hospital, Syosset, New York, United States
🇺🇸Franklin Hospital, Valley Stream, New York, United States
Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics
- First Posted Date
- 2008-06-06
- Last Posted Date
- 2023-07-12
- Lead Sponsor
- CareFusion
- Target Recruit Count
- 122
- Registration Number
- NCT00692484
- Locations
- 🇺🇸
BioScience Laboratories, Bozeman, Montana, United States
Wound Antiseptic Study With Hypochlorous Acid & Iodopovidone
- First Posted Date
- 2008-06-06
- Last Posted Date
- 2008-10-21
- Lead Sponsor
- Universidad Tecnológica de Pereira
- Target Recruit Count
- 432
- Registration Number
- NCT00692757
- Locations
- 🇨🇴
Hospital Universitario San Jorge (HUSJ), Pereira, Risaralda, Colombia
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine
- Conditions
- Fungal Keratitis
- Interventions
- First Posted Date
- 2007-08-15
- Last Posted Date
- 2014-12-04
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 78
- Registration Number
- NCT00516399
A Randomised Study to Assess Betadine in the Groin Wound of Patients Undergoing Primary Varicose Vein Surgery
- First Posted Date
- 2007-07-13
- Last Posted Date
- 2017-04-12
- Lead Sponsor
- Royal Hobart Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT00500669
- Locations
- 🇦🇺
Royal Hobart Hospital, Hobart, Tasmania, Australia
A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb
- Conditions
- Osteoarthritis
- Interventions
- Drug: Bupivicaine (local anesthesia injection)
- First Posted Date
- 2006-11-14
- Last Posted Date
- 2017-07-07
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 200
- Registration Number
- NCT00398866
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
- Conditions
- Infected Corneal UlcersBacterial KeratitisCorneal UlcerChildhood Blindness
- First Posted Date
- 2006-10-12
- Last Posted Date
- 2016-08-23
- Target Recruit Count
- 172
- Registration Number
- NCT00386958
- Locations
- 🇺🇸
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States
Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections
- Conditions
- Postoperative Wound Infection
- Interventions
- Drug: chlorhexidine-alcohol
- First Posted Date
- 2006-02-13
- Last Posted Date
- 2014-09-18
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 849
- Registration Number
- NCT00290290
- Locations
- 🇺🇸
Milwaukee VA Medical Center, Milwaukee, Wisconsin, United States
🇺🇸Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts, United States
🇺🇸Ben Taub General Hospital, Houston, Texas, United States
Study of Omiganan 1% Gel in Preventing Catheter Infections/Colonization in Patients With Central Venous Catheters
- First Posted Date
- 2005-10-04
- Last Posted Date
- 2009-08-13
- Lead Sponsor
- Cadence Pharmaceuticals
- Target Recruit Count
- 1859
- Registration Number
- NCT00231153
Study Of Combined VISUDYNE Therapy With Kenalog In CNV Secondary To Age-Related Macular Degeneration
- Conditions
- Age-Related Macular Degeneration
- First Posted Date
- 2005-09-01
- Last Posted Date
- 2007-07-12
- Lead Sponsor
- Manhattan Eye, Ear & Throat Hospital
- Target Recruit Count
- 106
- Registration Number
- NCT00140803
- Locations
- 🇨🇦
Vh/UBC Eye Care Centre, Vancouver, British Columbia, Canada
🇺🇸Manhattan Eye, Ear & Throat Hospital, New York, New York, United States
Drug Development Updates
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