Povidone-iodine

Generic Name: Povidone-iodine

Brand Names: Betadine, Kenalog, Marbeta, Marcaine, P-Care M, P-Care MG, P-care, P-care X, Summer's Eve Medicated

Drug Type: Small Molecule

CAS Number: 25655-41-8

Unique Ingredient Identifier: 85H0HZU99M

Background: Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. During in vitro testing to demonstrate anti-bacterial activity it was found that the complex was less toxic in mice than tincture of iodine. Human clinical trials showed the product to be superior to other iodine formulations. Povidone-iodine was immediately marketed, and has since become the universally preferred iodine antiseptic.

Indication: For topical application in the treatment and prevention of infection in wounds.

Associated Conditions: Skin Infections

Associated Therapies: Skin disinfection, Antiseptic skin preparation therapy, Irrigation of the ocular surface therapy, Prepping of the periocular region

Clinical Trials

Povidone-Iodine for Nasal Decolonization

Phase 4

Completed

Conditions: Methicillin-Resistant Staphylococcus Aureus
Surgical Wound Infection
Preoperative Care

Interventions: Drug: 0.9% NaCl Solution
Drug: Povidone-Iodine 10%

First Posted Date: 2022-09-06

Last Posted Date: 2024-11-13

Lead Sponsor: Rutgers, The State University of New Jersey

Target Recruit Count: 192

Registration Number: NCT05529173

Locations: 🇺🇸
University Hospital, Newark, New Jersey, United States

Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection

Phase 4

Conditions: Surgical Wound Infection

Interventions: Drug: Betadine
Drug: Vancomycin

First Posted Date: 2022-03-11

Last Posted Date: 2022-03-11

Lead Sponsor: Assiut University

Target Recruit Count: 80

Registration Number: NCT05276687

Treatment of Blepharitis With Povidone-Iodine 1%

Not Applicable

Conditions: Anterior Blepharitis

Interventions: Drug: Eyelid cleansing wipes
Drug: Povidone-Iodine 1 % Topical Solution

First Posted Date: 2021-12-16

Last Posted Date: 2021-12-16

Lead Sponsor: Shaare Zedek Medical Center

Target Recruit Count: 100

Registration Number: NCT05160623

Locations: 🇮🇱
Ophthalmology clinic, Shaare Zedek Medical Center, Jerusalem, Israel

Skip Prep of Vaginal Delivery to Prevent Puerperal / Perinatal Infection in Vaginal Delivery

Not Applicable

Not yet recruiting

Conditions: Vaginal Delivery
Surgical Site Infection

Interventions: Drug: Chlorhexidine
Drug: Povidone-Iodine

First Posted Date: 2021-11-16

Last Posted Date: 2021-11-26

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 4140

Registration Number: NCT05122169

Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement

Phase 3

Active, not recruiting

Conditions: Periprosthetic Joint Infection
Draining Wound

Interventions: Drug: Povidone-Iodine Lavage Solution
Drug: Chlorhexidine Lavage Solution
Drug: Topical Antibiotic
Drug: Saline Lavage Solution

First Posted Date: 2021-10-19

Last Posted Date: 2024-02-21

Lead Sponsor: Hamilton Health Sciences Corporation

Target Recruit Count: 500

Registration Number: NCT05084378

Locations: 🇨🇦
St. Joseph's Healthcare, Hamilton, Ontario, Canada
🇨🇦
Montreal General Hospital, Montreal, Quebec, Canada
🇨🇦
St. Mary's Hospital, Montreal, Quebec, Canada

and more 3 locations

Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine

Phase 4

Recruiting

Conditions: Eye Infections, Bacterial

Interventions: Drug: Betadine
Drug: Avenova

First Posted Date: 2021-07-29

Last Posted Date: 2024-11-27

Lead Sponsor: University of Miami

Target Recruit Count: 230

Registration Number: NCT04981860

Locations: 🇺🇸
Bascom Palmer Eye Institute, Palm Beach Gardens, Florida, United States
🇺🇸
Medical Center Ophthalmology Associates, San Antonio, Texas, United States