MedPath

Aminohippuric acid

Generic Name
Aminohippuric acid
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C9H10N2O3
CAS Number
61-78-9
Unique Ingredient Identifier
Y79XT83BJ9
Background

The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]

Indication

Used to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.

Associated Conditions
-
Associated Therapies
-

Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study

Conditions
Type 2 Diabetes
Diabetic Nephropathies
Adolescent Obesity
Diabetic Kidney Disease
Nephropathy
Obesity
Diabetes Type 2
Interventions
Drug: Aminohippurate Sodium Inj 20%
Drug: Iohexol Inj 300 MG/ML
Drug: Dextran 40
Procedure: Renal Biopsy
Radiation: Positron Emission Tomography
First Posted Date
2022-09-07
Last Posted Date
2022-11-02
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
100
Registration Number
NCT05530356
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

Renal Mechanism of SGLT2 Inhibition

Phase 2
Recruiting
Conditions
Type 2 Diabetes
Diabetic Kidney Disease
Interventions
First Posted Date
2022-08-19
Last Posted Date
2022-11-03
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
40
Registration Number
NCT05507892
Locations
🇺🇸

University of Colorado Denver, Aurora, Colorado, United States

🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

🇺🇸

University of Michigan, Ann Arbor, Michigan, United States

and more 1 locations

Pathogenesis of Kidney Disease in Type 1 Diabetes: a Modern Kidney Biopsy Cohort (The PANDA Study)

First Posted Date
2022-04-11
Last Posted Date
2024-04-10
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
100
Registration Number
NCT05319990
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes

Phase 1
Recruiting
Conditions
Type 1 Diabetes
Diabetic Kidney Disease
Cardiovascular Diseases
Endothelial Dysfunction
Insulin Sensitivity
Interventions
First Posted Date
2021-10-04
Last Posted Date
2024-06-13
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
60
Registration Number
NCT05065372
Locations
🇺🇸

University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

Recruiting
Conditions
Diabetic Kidney Disease
Adolescent Obesity
Kidney Hypoxia
Puberty
Type 2 Diabetes Mellitus
Pre Diabetes
Interventions
First Posted Date
2021-08-17
Last Posted Date
2024-04-11
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
100
Registration Number
NCT05008276
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3

Phase 4
Recruiting
Conditions
Heart Failure
Interventions
First Posted Date
2020-12-02
Last Posted Date
2024-03-05
Lead Sponsor
Yale University
Target Recruit Count
80
Registration Number
NCT04649229
Locations
🇺🇸

Yale New Haven Hospital, New Haven, Connecticut, United States

PErfusioN, OxyGen ConsUmptIon and ENergetics in ADPKD (PENGUIN)

Completed
Conditions
Polycystic Kidney Disease, Adult
Polycystic Kidney, Autosomal Dominant
Interventions
First Posted Date
2020-05-29
Last Posted Date
2023-02-03
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
22
Registration Number
NCT04407481
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2

Phase 4
Recruiting
Conditions
Heart Failure
Interventions
First Posted Date
2019-10-02
Last Posted Date
2024-03-05
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
80
Registration Number
NCT04113109
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Control of Renal Oxygen Consumption, Mitochondrial Dysfunction, and Insulin Resistance

Completed
Conditions
Type 1 Diabetes
Diabetes
Diabetes Mellitus
Type1diabetes
Diabetes, Autoimmune
Diabetic Kidney Disease
Diabetes Complications
Diabetic Nephropathies
Autoimmune Diabetes
Juvenile Diabetes
Interventions
First Posted Date
2019-08-30
Last Posted Date
2023-02-09
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
58
Registration Number
NCT04074668
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes

Phase 1
Active, not recruiting
Conditions
Diabetes Complications
Weight Loss
Diabetic Nephropathies
Type 2 Diabetes Mellitus
Obesity
Bariatric Surgery Candidate
Nephropathy
Diabetic Kidney Disease
Diabetes Mellitus, Type 2
Diabetes Mellitus
Interventions
Drug: Aminohippurate Sodium Inj 20%
Drug: Iohexol Inj 300 mg/mL
Procedure: Vertical Sleeve Gastrectomy
Procedure: Renal Biopsy
First Posted Date
2018-08-08
Last Posted Date
2024-04-05
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
30
Registration Number
NCT03620773
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

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