Rosuvastatin

Generic Name: Rosuvastatin

Brand Names: Crestor, Ezallor, Roszet

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₈FN_₃O_₆S

CAS Number: 287714-41-4

Unique Ingredient Identifier: 413KH5ZJ73

Background: Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the e...

Indication: The FDA monograph states that rosuvastatin is indicated as an adjunct to diet in the treatment of triglyceridemia, Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia), and Homozygous Familial Hypercholesterolemia.
...

Associated Conditions: Atherosclerosis, Atherosclerotic Cardiovascular Diseases, Cardiovascular Disease (CVD), Cardiovascular Events, Dysbetalipoproteinemia, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Homozygous Familial Hypercholesterolaemia (HoFH), Hypertension, Hypertension, Essential Hypertension, Hypertriglyceridemias, Major Adverse Cardiovascular Events, Mixed Dyslipidemias, Postoperative Thromboembolism, Primary Hypercholesterolemia, Primary Hyperlipidemia

Associated Therapies: Lipid-Lowering Therapy, Primary Prevention of Cardiovascular Diseases

Clinical Trials

A Drug Drug Interaction (DDI) Study of Selpercatinib (LY3527723) and Rosuvastatin in Healthy Participants

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Rosuvastatin
Drug: Selpercatinib

First Posted Date: 2023-06-18

Last Posted Date: 2024-01-05

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 32

Registration Number: NCT05906836

Locations: 🇺🇸
Labcorp Clinical Research LP, Dallas, Texas, United States

A Study to Learn About the Study Medicine Called Nirmatrelvir/Ritonavir in People Who Are Healthy Volunteers Co-administered the Medicine Rosuvastatin

Phase 1

Completed

Conditions: Pharmacokinetics
Healthy Volunteers

Interventions: Drug: Rosuvastatin
Drug: Nirmatrelvir/ritonavir

First Posted Date: 2023-06-12

Last Posted Date: 2024-10-28

Lead Sponsor: Pfizer

Target Recruit Count: 12

Registration Number: NCT05898672

Locations: 🇧🇪
Pfizer Clinical Research Unit - Brussels, Brussels, Bruxelles-capitale, Région DE, Belgium

Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine

Phase 4

Recruiting

Conditions: Coronary Artery Disease

Interventions: Drug: Placebo
Drug: Rosuvastatin
Drug: Colchicine

First Posted Date: 2023-05-09

Last Posted Date: 2024-05-09

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 200

Registration Number: NCT05850091

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

Phase 2

Recruiting

Conditions: Cirrhosis
Cirrhosis, Liver
Cirrhosis Early
Cirrhosis Due to Hepatitis B
Cirrhosis Advanced
Cirrhosis Infectious
Cirrhosis Alcoholic
Cirrhosis Due to Hepatitis C

Interventions: Drug: Rosuvastatin

First Posted Date: 2023-04-27

Last Posted Date: 2024-12-17

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 256

Registration Number: NCT05832229

Locations: 🇺🇸
University of California San Diego NAFLD Research Center, La Jolla, California, United States
🇺🇸
Keck Medical Center of USC, Los Angeles, California, United States
🇺🇸
LAC + USC Medical Center, Los Angeles, California, United States

and more 10 locations