Tazobactam
- Generic Name
- Tazobactam
- Brand Names
- Zerbaxa, Zosyn
- Drug Type
- Small Molecule
- Chemical Formula
- C10H12N4O5S
- CAS Number
- 89786-04-9
- Unique Ingredient Identifier
- SE10G96M8W
- Background
Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with Piperacillin and Ceftolozane for the treatment of a variety of bacterial infections.
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- Indication
临床上他唑巴坦常与β内酰胺类抗生素联合应用，可用于治疗敏感细菌所致的下呼吸道、腹腔、妇科、泌尿、骨和关节、皮肤组织等部位的感染和败血症。也可用于多种细菌的混合感染和患中性粒细胞缺乏者的感染。
- Associated Conditions
- Complicated Urinary Tract Infection, Nosocomial Pneumonia, Pyelonephritis, Ventilator Associated Bacterial Pneumonia (VABP), Complicated intra-abdominal bacterial infections
- Associated Therapies
- -
Comparative Study To Determine The Efficacy, Safety, And Tolerability Of Ceftolozane-Tazobactam
Phase 2
Completed
- Conditions
- Interventions
- First Posted Date
- 2018-04-03
- Last Posted Date
- 2022-03-15
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 100
- Registration Number
- NCT03485950
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014)
Phase 3
Completed
- Conditions
- Interventions
- First Posted Date
- 2015-07-09
- Last Posted Date
- 2020-04-16
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 537
- Registration Number
- NCT02493764
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