Modafinil
- Generic Name
- Modafinil
- Brand Names
- Provigil
- Drug Type
- Small Molecule
- Chemical Formula
- C15H15NO2S
- CAS Number
- 68693-11-8
- Unique Ingredient Identifier
- R3UK8X3U3D
- Background
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactiva...
- Indication
To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
- Associated Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Fatigue, Major Depressive Disorder (MDD), Narcolepsy, Obstructive Sleep Apnea (OSA), Shift-work related sleep disturbance
- Associated Therapies
- -
Phase 2, Multi-Center Trial of Modafinil for Methamphetamine Dependence
- First Posted Date
- 2007-08-24
- Last Posted Date
- 2017-04-07
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 210
- Registration Number
- NCT00520286
- Locations
- 🇺🇸
Powell Chemical Dependency Center, Des Moines, Iowa, United States
🇺🇸Matrix Institute on Addictions, Tarzana, California, United States
🇺🇸University of Colorado Health Sciences Center, Denver, Colorado, United States
Efficacy of Pharmacological Treatment of Working Memory Impairment After Traumatic Brain Injury: Evaluation With fMRI
- Conditions
- First Posted Date
- 2007-06-21
- Last Posted Date
- 2007-07-25
- Lead Sponsor
- Kessler Foundation
- Target Recruit Count
- 20
- Registration Number
- NCT00489892
- Locations
- 🇺🇸
Kessler Medical Rehabilitation Research & Education Corporation, West Orange, New Jersey, United States
Modafinil vs Placebo for the Treatment of Methamphetamine Dependence
- First Posted Date
- 2007-05-04
- Last Posted Date
- 2020-03-02
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 71
- Registration Number
- NCT00469508
- Locations
- 🇺🇸
UCLA Vine Street Clinic, Hollywood, California, United States
Substance Abuse Pre-Treatment Screening Study
- First Posted Date
- 2007-02-22
- Last Posted Date
- 2023-12-20
- Target Recruit Count
- 7500
- Registration Number
- NCT00439049
- Locations
- 🇺🇸
University of Texas Medical School- Houston, Dept. of Psychiatry Mental Sciences Institute, Houston, Texas, United States
A Safety and Effectiveness Study of a Single Dose of JNJ-17216498 in Patients With Narcolepsy
- First Posted Date
- 2007-01-22
- Last Posted Date
- 2014-05-23
- Lead Sponsor
- Alza Corporation, DE, USA
- Target Recruit Count
- 16
- Registration Number
- NCT00424931
Modafinil for Treatment of Cognitive Dysfunction in Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2007-01-18
- Last Posted Date
- 2017-09-29
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 33
- Registration Number
- NCT00423943
- Locations
- 🇺🇸
University of California Los Angeles School of Medicine, Los Angeles, California, United States
Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning
- Conditions
- Interventions
- First Posted Date
- 2007-01-05
- Last Posted Date
- 2020-09-23
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 34
- Registration Number
- NCT00418691
- Locations
- 🇺🇸
U.T.M.D. Anderson Cancer Center, Houston, Texas, United States
Comparison of Modafinil and Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients With Parkinson's Disease
- Conditions
- First Posted Date
- 2006-10-29
- Last Posted Date
- 2015-06-26
- Lead Sponsor
- US Department of Veterans Affairs
- Registration Number
- NCT00393562
- Locations
- 🇺🇸
Philadelphia, OPC, Philadelphia, Pennsylvania, United States
Modafinil Treatment for Cocaine Dependence and HIV High-Risk Behavior
- Conditions
- Interventions
- First Posted Date
- 2006-08-24
- Last Posted Date
- 2018-03-15
- Lead Sponsor
- Kyle Kampman
- Target Recruit Count
- 94
- Registration Number
- NCT00368290
A Placebo-Controlled Double-Blind Combined Treatment of Modafinil and CBT for Cocaine Dependence
- Conditions
- Interventions
- First Posted Date
- 2006-06-27
- Last Posted Date
- 2012-12-03
- Lead Sponsor
- Research Foundation for Mental Hygiene, Inc.
- Target Recruit Count
- 15
- Registration Number
- NCT00344565
Drug Development Updates
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