MedPath

ralmitaront

Generic Name
ralmitaront

18F-Dihydroxyphenylalanine (DOPA) Positron Emission Tomography (PET) Study to Explore Dopamine Synthesis Capacity in the Whole Striatum After 2 Weeks of Treatment With Ralmitaront or Placebo in Participants With Schizophrenia

Phase 1
Completed
Conditions
Schizophrenia
Interventions
Other: Radiolabeled PET tracer [18F]-DOPA
Drug: Placebo
First Posted Date
2025-03-17
Last Posted Date
2025-03-17
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
35
Registration Number
NCT06880328
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Parexel California Clinical Trials Medical Group, Glendale, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

Collaborative Neuroscience Network Inc., Torrance, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

CBH Health, Gaithersburg, Maryland, United States

and more 1 locations

A Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder

Phase 2
Completed
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
First Posted Date
2020-08-13
Last Posted Date
2023-10-10
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
287
Registration Number
NCT04512066
Locations
๐Ÿ‡บ๐Ÿ‡ธ

CNRI - Los Angeles, LLC, Pico Rivera, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

Neuro-Behavioral Clinical Research, Inc., Canton, Ohio, United States

๐Ÿ‡บ๐Ÿ‡ธ

Uptown Research Institute, Chicago, Illinois, United States

and more 36 locations

A Study to Assess the Effects of RO6889450 (Ralmitaront) in Participants With Schizophrenia or Schizoaffective Disorder and Negative Symptoms

Phase 2
Terminated
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Drug: Placebo
First Posted Date
2018-09-13
Last Posted Date
2024-08-12
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
131
Registration Number
NCT03669640
Locations
๐Ÿ‡บ๐Ÿ‡ธ

California Neuropsychopharmacology Clinical Research Institute, LLC, San Diego, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

Synergy San Diego, Lemon Grove, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

Emory University, Atlanta, Georgia, United States

and more 41 locations

The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RO6889450 in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy Volunteer
Interventions
Drug: Placebo
First Posted Date
2016-03-04
Last Posted Date
2017-11-24
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
164
Registration Number
NCT02699372
Locations
๐Ÿ‡ณ๐Ÿ‡ฑ

PRA Health Sciences Early Development Services, Zuidlaren, Netherlands

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