Collagenase clostridium histolyticum
- Generic Name
- Collagenase clostridium histolyticum
- Brand Names
- Qwo, Santyl, Xiaflex
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 9001-12-1
- Unique Ingredient Identifier
- 9X7O8V25IT
- Background
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers.
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- Indication
Collagenase clostridium histolyticum is indicated for the treatment of adults with Dupuytren's contracture with a palpable cord. Additionally, it is used to treat men with Peyronie's disease diagnosed with a penile curvature deformity of at least a 30-degree angle at the beginning of therapy in addition to palpable plaques. Collagenase ointment is used for t...
- Associated Conditions
- Dupuytren's Contracture of the Hand (Viking's Disease), Peyronie's Disease, Necrotic tissue
- Associated Therapies
- -
Delayed Dose Collagenase Clostridium Histolyticum (CCH) Protocol for Men With Peyronie's Disease
- Conditions
- Interventions
- First Posted Date
- 2024-10-18
- Last Posted Date
- 2024-10-18
- Target Recruit Count
- 40
- Registration Number
- NCT06649539
- Locations
- 🇺🇸
Male Fertility and Peyronie's Clinic, Orem, Utah, United States
Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease
- Conditions
- Interventions
- First Posted Date
- 2023-10-04
- Last Posted Date
- 2024-04-16
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 60
- Registration Number
- NCT06065436
- Locations
- 🇺🇸
Mayo Clinic Minnesota, Rochester, Minnesota, United States
Focused Shock Wave Therapy Outcomes in Peyronie's Disease and Erectile Dysfunction
- Conditions
- Interventions
- First Posted Date
- 2022-12-12
- Last Posted Date
- 2023-10-10
- Lead Sponsor
- Mayo Clinic
- Registration Number
- NCT05646602
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Effect of Oral TXA on Buttock Bruising Post CCH Injections in Adult Females
- Conditions
- Interventions
- First Posted Date
- 2022-04-04
- Last Posted Date
- 2023-03-08
- Lead Sponsor
- Luxurgery
- Target Recruit Count
- 17
- Registration Number
- NCT05309525
- Locations
- 🇺🇸
Luxurgery, New York, New York, United States
To Assess the Effectiveness of Multiple Dose, Multiple Concentrations of Qwo, for the Treatment of Mild to Moderate Cellulite.
- First Posted Date
- 2021-08-30
- Last Posted Date
- 2021-09-21
- Lead Sponsor
- DMR Research, PLLC
- Target Recruit Count
- 5
- Registration Number
- NCT05026216
- Locations
- 🇺🇸
DMR Research, PLLC, Westport, Connecticut, United States
CCH Treatment of Cellulite in the Presence of Dermal Laxity With Comparison Between Two (2) Different Injection Techniques
- Conditions
- Interventions
- First Posted Date
- 2020-10-08
- Last Posted Date
- 2022-09-28
- Lead Sponsor
- Endo Pharmaceuticals
- Target Recruit Count
- 35
- Registration Number
- NCT04580303
- Locations
- 🇺🇸
Endo Clinical Trial Site #2, Metairie, Louisiana, United States
🇺🇸Endo Clinical Trial Site #3, Coral Gables, Florida, United States
🇺🇸Endo Clinical Trial Site #1, New York, New York, United States
Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease
- Conditions
- Interventions
- First Posted Date
- 2018-01-23
- Last Posted Date
- 2023-11-08
- Lead Sponsor
- Region Skane
- Target Recruit Count
- 60
- Registration Number
- NCT03406338
- Locations
- 🇸🇪
Department of Orthopedics Hässleholm-Kristianstad, Hässleholm, Sweden
Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease
- Conditions
- Interventions
- First Posted Date
- 2016-12-21
- Last Posted Date
- 2016-12-21
- Lead Sponsor
- University of Calgary
- Target Recruit Count
- 334
- Registration Number
- NCT03000114
- Locations
- 🇨🇦
University of Calgary, Calgary, Alberta, Canada
MEDIHONEY® Gel Versus Collagenase for Wound Debridement
- Conditions
- Interventions
- First Posted Date
- 2015-06-26
- Last Posted Date
- 2017-12-02
- Lead Sponsor
- Integra LifeSciences Corporation
- Target Recruit Count
- 10
- Registration Number
- NCT02482948
- Locations
- 🇺🇸
Innovative Healing Systems, Tampa, Florida, United States
Short-term Function and Pain After Treatment for Dupuytren's Disease
- First Posted Date
- 2014-11-25
- Last Posted Date
- 2016-12-06
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 60
- Registration Number
- NCT02301078
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Division of Plastic and Reconstructive Surgery, Toronto, Ontario, Canada
Drug Development Updates
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