Ketoconazole

Generic Name: Ketoconazole

Brand Names: Extina, Ketodan, Ketoderm, Nizoral, Xolegel, Ketoconazole HRA

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₈Cl_₂N_₄O_₄

CAS Number: 65277-42-1

Unique Ingredient Identifier: R9400W927I

Background: Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections. It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus. Ketoconazole was first approved in an oral formulation for systemic use by...

Indication: Ketoconazole is used in the treatment or prevention of fungal infections including blastomycosis, candidiasis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. In Europe, it is also used in the treatment of endogenous Cushing's syndrome.

Associated Conditions: Bacterial Vaginosis (BV), Blastomycosis, Candidiasis, Systemic, Chromoblastomycosis, Chronic Mucocutaneous Candidiasis (CMC), Coccidioidomycosis, Dandruff, Endogenous Cushing's Syndrome, Fungal Infections, Histoplasmosis, Paracoccidioidomycosis, Seborrheic Dermatitis, Tinea Corporis caused by Epidermophyton floccosumin, Tinea Corporis caused by Trichophyton mentagrophytes, Tinea Corporis caused by Trichophyton rubrum, Tinea Cruris caused by Epidermophyton floccosumin, Tinea Cruris caused by Trichophyton mentagrophytes, Tinea Cruris caused by Trichophyton rubrum, Tinea Pedis caused by Epidermophyton floccosumin, Tinea Pedis caused by Trichophyton mentagrophytes, Tinea Pedis caused by Trichophyton rubrum, Vaginal Candidiasis, Vulvovaginal Candidiasis, Cutaneous candidiasis, Recalcitrant Dermatophytosis, Tinea versicolor caused by Malassezia infection

Associated Therapies: -

Clinical Trials

Ketoconazole Contributes to Cryptorchidism Outcome Via Modulating Macrophage Trem2

Not Applicable

Recruiting

Conditions: Cryptorchidism

Interventions: Drug: Ketoconazole
Drug: Luteinizing Hormone

First Posted Date: 2024-08-19

Last Posted Date: 2024-08-19

Lead Sponsor: Affiliated Hospital of Nantong University

Target Recruit Count: 10

Registration Number: NCT06560086

Locations: 🇨🇳
Affiliated hospital of nantong university, Nantong, Jiangsu, China

Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas

Early Phase 1

Recruiting

Conditions: Glioblastoma Multiforme
Glioblastoma
Glioblastoma Multiforme of Brain
Glioblastoma Multiforme, Adult

Interventions: Drug: Ketoconazole

First Posted Date: 2021-05-03

Last Posted Date: 2024-11-18

Lead Sponsor: Milton S. Hershey Medical Center

Target Recruit Count: 5

Registration Number: NCT04869449

Locations: 🇺🇸
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States

Bioavailability of Levoketoconazole and Ketoconazole Tablets

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Levoketoconazole
Drug: Ketoconazole

First Posted Date: 2019-12-26

Last Posted Date: 2020-01-31

Lead Sponsor: Cortendo AB

Target Recruit Count: 34

Registration Number: NCT04212000

Locations: 🇺🇸
Pharmaceutical Research Associates, Inc., Salt Lake City, Utah, United States

Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases

Early Phase 1

Terminated

Conditions: Glioma
Anatomic Stage IV Breast Cancer AJCC v8
Astrocytoma
Recurrent Glioma
Breast Carcinoma Metastatic in the Brain
Invasive Breast Carcinoma
Oligodendroglioma
Prognostic Stage IV Breast Cancer AJCC v8

Interventions: Other: Best Practice
Drug: Ketoconazole

First Posted Date: 2019-01-08

Last Posted Date: 2024-08-15

Lead Sponsor: Wake Forest University Health Sciences

Target Recruit Count: 15

Registration Number: NCT03796273

Locations: 🇺🇸
Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

Omiganan Twice a Day (BID) in Patients With Facial Seborrheic Dermatitis

Phase 2

Conditions: Seborrheic Dermatitis

Interventions: Drug: Omiganan
Drug: Placebo
Drug: Ketoconazole

First Posted Date: 2018-09-28

Last Posted Date: 2019-05-01

Lead Sponsor: Maruho Co., Ltd.

Target Recruit Count: 36

Registration Number: NCT03688971

Locations: 🇳🇱
Centre for Human Drug Research, Leiden, Netherlands

Ketoconazole Gel Versus Terconazole Cream for Vaginal Candidiasis

Phase 3

Conditions: Vaginal Candidiasis

Interventions: Drug: Terconazole
Drug: Ketoconazole

First Posted Date: 2018-03-22

Last Posted Date: 2018-03-22

Lead Sponsor: Assiut University

Target Recruit Count: 69

Registration Number: NCT03473418

Ketoconazole in Treating Participants With Ongoing EGFR Inhibitor-Induced Rash

Early Phase 1

Active, not recruiting

Conditions: Malignant Neoplasm

Interventions: Drug: Ketoconazole
Other: Placebo Administration
Other: Laboratory Biomarker Analysis
Other: Quality-of-Life Assessment
Other: Questionnaire Administration

First Posted Date: 2018-03-20

Last Posted Date: 2024-08-01

Lead Sponsor: Mayo Clinic

Target Recruit Count: 26

Registration Number: NCT03471364

Locations: 🇺🇸
Carle Cancer Center, Urbana, Illinois, United States
🇺🇸
Carle on Vermilion, Danville, Illinois, United States
🇺🇸
Park Nicollet Frauenshuh Cancer Center, Saint Louis Park, Minnesota, United States

and more 3 locations