Chlorhexidine

Generic Name
Chlorhexidine
Brand Names
Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur
Drug Type
Small Molecule
Chemical Formula
C22H30Cl2N10
CAS Number
55-56-1
Unique Ingredient Identifier
R4KO0DY52L
Background

Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...

Indication

Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...

Associated Conditions
Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation
Associated Therapies
Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection
Clinical Trials
Related News

The Effects of Pistacia Mutica on De Novo Dental Plaque Formation, Gingival Inflammation and Oral Microorganisms

First Posted Date
2009-09-09
Last Posted Date
2009-09-09
Lead Sponsor
Tabriz University
Target Recruit Count
25
Registration Number
NCT00972803
Locations
🇮🇷

Drug Applied Science Center, tabriz Univ. of Medical Sciences, Tabriz, East azarbaijan, Iran, Islamic Republic of

Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants

Not Applicable
Completed
Conditions
Neonatal Sepsis
Low Birth Weight
Interventions
Drug: Normal saline
Drug: Chlorhexidine
First Posted Date
2009-07-28
Last Posted Date
2018-06-25
Lead Sponsor
All India Institute of Medical Sciences, New Delhi
Target Recruit Count
60
Registration Number
NCT00947518

Triamcinolone Paste to Reduce the Incidence of Postoperative Sore Throat

First Posted Date
2009-05-27
Last Posted Date
2009-05-27
Lead Sponsor
Soonchunhyang University Hospital
Target Recruit Count
150
Registration Number
NCT00908817
Locations
🇰🇷

Soonchunhyang University, College of medicine Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, Bucheon-Si, Gyeonggi-Do, Korea, Republic of

Chlorhexidine & Pneumonia in Nursing Home Residents

First Posted Date
2009-02-11
Last Posted Date
2017-04-14
Lead Sponsor
University of Louisville
Target Recruit Count
75
Registration Number
NCT00841074
Locations
🇺🇸

University of Louisville, Louisville, Kentucky, United States

Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent Methicillin-resistant Staphylococcus Aureus & Other Hospital Infections

First Posted Date
2008-10-24
Last Posted Date
2018-05-15
Lead Sponsor
Christiana Care Health Services
Target Recruit Count
1518
Registration Number
NCT00779246
Locations
🇺🇸

Christiana Hospital, Newark, Delaware, United States

Training and Calibration of Dental Examiners

First Posted Date
2008-10-02
Last Posted Date
2008-10-03
Lead Sponsor
Colgate Palmolive
Target Recruit Count
18
Registration Number
NCT00765167
Locations
🇺🇸

UMDNJ Dental School, Newark, New Jersey, United States

Evaluate Clinical Research From Commerical Oral Care Products

First Posted Date
2008-09-25
Last Posted Date
2010-03-04
Lead Sponsor
Colgate Palmolive
Target Recruit Count
25
Registration Number
NCT00759187
Locations
🇺🇸

Boston University School of Dental Medicine, Boston, Massachusetts, United States

Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics

Phase 3
Completed
Conditions
Healthy
Interventions
Drug: Chlorhexidine gluconate
Drug: Povidone iodine
First Posted Date
2008-06-06
Last Posted Date
2023-07-12
Lead Sponsor
CareFusion
Target Recruit Count
122
Registration Number
NCT00692484
Locations
🇺🇸

BioScience Laboratories, Bozeman, Montana, United States

Preoperative Skin Preparation Evaluation

First Posted Date
2008-03-14
Last Posted Date
2021-05-03
Lead Sponsor
CareFusion
Target Recruit Count
60
Registration Number
NCT00636480
Locations
🇺🇸

BioScience Laboratories, Bozeman, Montana, United States

The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries

First Posted Date
2008-02-11
Last Posted Date
2008-02-11
Lead Sponsor
Universidade Federal do Ceara
Target Recruit Count
69
Registration Number
NCT00612469
Locations
🇧🇷

School of Dentistry, Department of Clinical Dentistry, Federal University of Ceara, Fortaleza, Ceara, Brazil

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