Chlorhexidine

Generic Name: Chlorhexidine

Brand Names: Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₃₀Cl_₂N_₁₀

CAS Number: 55-56-1

Unique Ingredient Identifier: R4KO0DY52L

Background: Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain. Topical chlorhexidine for disinfection, as well as oral rinses for dental use, carries activity against a broad range of pathogens including bacteria, yeasts, and viruses.

Chlorhexidine was developed in the UK by Imperial Chemical Industries in the early 1950s and was introduced to the US in the 1970s. The FDA withdrew its approval for the use of chlorhexidine gluconate topical tincture 0.5%, due to a significant number of reports concerning chemical and thermal burns associated with the use of this product. Other formulations of chlorhexidine continue to be available.

Indication: Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodontal pockets and is indicated for the reduction of pocket depth in adult patients with periodontitis as an adjunct therapy to dental scaling and root planing procedures.

Associated Conditions: Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation

Associated Therapies: Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection

Clinical Trials

Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth

Not Applicable

Conditions: Necrotic Pulp

Interventions: Drug: chitosan gel
Drug: chitosan nanoparticles gel
Drug: chlorhexidine gluconate

First Posted Date: 2018-07-17

Last Posted Date: 2018-07-17

Lead Sponsor: Ain Shams University

Target Recruit Count: 45

Registration Number: NCT03588351

Locations: 🇪🇬
Ain shames university faculty of dentistry, Cairo, Egypt

Comfort and Antimicrobial Efficacy of Chlorhexidine vs Betadine for Intravitreal Injections

Early Phase 1

Conditions: Age-related Macular Degeneration
Diabetic Vascular Diseases
Proliferative Retinopathy
Retina Vein Occlusion

Interventions: Drug: Povidine-Iodine
Drug: Chlorhexidine

First Posted Date: 2018-06-27

Last Posted Date: 2018-06-27

Lead Sponsor: MidAtlantic Retina

Target Recruit Count: 100

Registration Number: NCT03571100

Locations: 🇺🇸
MidAtlantic Retina, Philadelphia, Pennsylvania, United States

Preventing Diabetic Foot Ulcers Through Cleaner Feet

Phase 2

Completed

Conditions: Diabetic Foot Ulcer

Interventions: Drug: Placebo
Drug: Chlorhexidine

First Posted Date: 2018-04-19

Last Posted Date: 2024-08-09

Lead Sponsor: VA Office of Research and Development

Target Recruit Count: 175

Registration Number: NCT03503370

Locations: 🇺🇸
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland, United States

Evaluation of the Preventive Effect of Chlorhexidine Acetate Gargle for Upper Gastrointestinal Tract Infection After ESD

Not Applicable

Conditions: Esophageal Cancer
Gastric Cancer

Interventions: Drug: chlorhexidine acetate gargle

First Posted Date: 2018-04-10

Last Posted Date: 2018-04-10

Lead Sponsor: Peking University Third Hospital

Target Recruit Count: 306

Registration Number: NCT03492827

Locations: 🇨🇳
Peking University Third Hospital, Beijing, Beijing, China

STaph Aureus Resistance-Treat Early and Repeat (STAR-TER)

Phase 2

Recruiting

Conditions: Cystic Fibrosis

Interventions: Drug: Trimethoprim Sulfamethoxazole (TMP/SMX)
Drug: Minocycline
Drug: Mupirocin
Drug: Chlorhexidine Gluconate
Behavioral: Environmental Decontamination

First Posted Date: 2018-04-05

Last Posted Date: 2024-04-09

Lead Sponsor: University of North Carolina, Chapel Hill

Target Recruit Count: 42

Registration Number: NCT03489629

Locations: 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
🇺🇸
Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, United States
🇺🇸
University of Washington Medical Center and Seattle Children's, Seattle, Washington, United States

and more 6 locations