Chlorhexidine

Generic Name: Chlorhexidine

Brand Names: Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₃₀Cl_₂N_₁₀

CAS Number: 55-56-1

Unique Ingredient Identifier: R4KO0DY52L

Background: Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...

Indication: Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...

Associated Conditions: Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation

Associated Therapies: Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection

Clinical Trials

Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis and Gingivitis

Phase 2

Completed

Conditions: Mucositis
Gingivitis

Interventions: Drug: Chlorhexidine gluconate
Drug: Placebo

First Posted Date: 2015-12-24

Last Posted Date: 2015-12-24

Lead Sponsor: Universidade Federal do Rio Grande do Norte

Target Recruit Count: 29

Registration Number: NCT02639377

Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis

Phase 2

Completed

Conditions: Mucositis

Interventions: Drug: Chlorhexidine gluconate
Drug: placebo

First Posted Date: 2015-11-16

Last Posted Date: 2015-11-16

Lead Sponsor: Universidade Federal do Rio Grande do Norte

Target Recruit Count: 37

Registration Number: NCT02605382

Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization

Phase 2

Completed

Conditions: S. Aureus Oropharyngeal Colonization

Interventions: Drug: Saline Placebo
Drug: Chlorhexidine gluconate

First Posted Date: 2015-10-28

Last Posted Date: 2020-12-29

Lead Sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Target Recruit Count: 67

Registration Number: NCT02589067

Locations: 🇺🇸
Los Angeles BioMedical Research Institute (LA BioMed), Torrance, California, United States

Staph Household Intervention for Eradication (SHINE)

Phase 4

Active, not recruiting

Conditions: Skin and Subcutaneous Tissue Bacterial Infections
Staphylococcus Aureus
MRSA - Methicillin Resistant Staphylococcus Aureus Infection

Interventions: Drug: Chlorhexidine
Drug: Mupirocin
Behavioral: Household cleaning

First Posted Date: 2015-10-09

Last Posted Date: 2024-05-23

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 835

Registration Number: NCT02572791

Locations: 🇺🇸
St. Louis Children's Hospital, Saint Louis, Missouri, United States
🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States