Chlorhexidine

Generic Name
Chlorhexidine
Brand Names
Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur
Drug Type
Small Molecule
Chemical Formula
C22H30Cl2N10
CAS Number
55-56-1
Unique Ingredient Identifier
R4KO0DY52L
Background

Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...

Indication

Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...

Associated Conditions
Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation
Associated Therapies
Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection
Clinical Trials
Related News

"The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients.

First Posted Date
2014-06-03
Last Posted Date
2014-06-03
Lead Sponsor
Tatyasaheb Kore Dental College
Target Recruit Count
60
Registration Number
NCT02154594
Locations
🇮🇳

Tatyasaheb Kore Dental College and Research Centre, Kolhapur, Maharashtra, India

Spectrophotometric Evaluation of Chlorhexidine Pigmentations After Oral Surgery: a Prospective Randomized Clinical Trial

Phase 2
Completed
Conditions
Staining Effect of Chlorhexidine
Interventions
Drug: Chlorhexidine
First Posted Date
2014-05-07
Last Posted Date
2014-05-07
Lead Sponsor
dott. Lorenzo Bevilacqua
Target Recruit Count
60
Registration Number
NCT02132546
Locations
🇮🇹

Ospedale Maggiore, Trieste, Italy

A New Antibiotic Prophylaxis Regimen to Prevent Bacteremia Following Dental Procedures

First Posted Date
2014-04-16
Last Posted Date
2015-05-27
Lead Sponsor
University of Santiago de Compostela
Target Recruit Count
266
Registration Number
NCT02115776
Locations
🇪🇸

Santiago de Compostela University Hospital, Santiago de Compostela, Coruña, Spain

🇪🇸

Hospital Clinico Universitario de Santiago, Santiago de Compostela, A Coruña, Spain

Chlorhexidine Drying Time

Completed
Conditions
Drying Time
Interventions
Drug: Chlorhexidine gluconate
First Posted Date
2014-03-24
Last Posted Date
2017-08-07
Lead Sponsor
University of British Columbia
Target Recruit Count
20
Registration Number
NCT02095535
Locations
🇨🇦

BC Women's Hospital, Vancouver, British Columbia, Canada

Methods of Chlorhexidine Cleansing to Prevent Ventilator-Associated Pneumonia (VAP)

First Posted Date
2014-03-04
Last Posted Date
2019-08-14
Lead Sponsor
General Hospital of Shenyang Military Region
Target Recruit Count
192
Registration Number
NCT02077920
Locations
🇨🇳

The General Hospital of Shenyang Military Region, Shenyang, Liaoning, China

Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects

First Posted Date
2014-02-13
Last Posted Date
2014-02-13
Lead Sponsor
University of Guarulhos
Target Recruit Count
60
Registration Number
NCT02062047

Effect of Chlorhexidine on Bacteriuria

First Posted Date
2014-01-10
Last Posted Date
2014-01-10
Lead Sponsor
Mashhad University of Medical Sciences
Target Recruit Count
105
Registration Number
NCT02032394
Locations
🇮🇷

Shahid Beheshti Hospital, Babol, Mazandaran, Iran, Islamic Republic of

The Amputation Surgical Site Infection Trial (ASSIT)

First Posted Date
2013-12-23
Last Posted Date
2019-07-15
Lead Sponsor
Hull University Teaching Hospitals NHS Trust
Target Recruit Count
160
Registration Number
NCT02018094
Locations
🇬🇧

Hull Royal Infirmary, Hull, United Kingdom

Effect of Chlorhexidine Gel on Bacterial Count During Fixed Orthodontic Treatment

First Posted Date
2013-12-04
Last Posted Date
2013-12-04
Lead Sponsor
King Abdulaziz University
Target Recruit Count
20
Registration Number
NCT02001311

An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining

First Posted Date
2013-10-14
Last Posted Date
2015-03-03
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
160
Registration Number
NCT01962493
Locations
🇬🇧

Intertek 4-Front Research - Widnes, Widnes, Cheshire, United Kingdom

🇬🇧

Intertek - Manchester Science Park, Manchester, United Kingdom

🇬🇧

Intertek - Maldon (formerly 4 Front Research Ltd), Maldon, Essex, United Kingdom

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