Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
A Study of TRV130 for the Treatment of Pain After Abdominoplasty
- First Posted Date
- 2015-01-09
- Last Posted Date
- 2020-09-16
- Lead Sponsor
- Trevena Inc.
- Target Recruit Count
- 200
- Registration Number
- NCT02335294
Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy
- First Posted Date
- 2014-12-31
- Last Posted Date
- 2018-11-30
- Lead Sponsor
- B.P. Koirala Institute of Health Sciences
- Target Recruit Count
- 90
- Registration Number
- NCT02327923
- Locations
- 🇳🇵
BP Koirala Institute of Health Sciences, Dharan, Sunsari District, Nepal
Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-12-11
- Last Posted Date
- 2019-03-13
- Target Recruit Count
- 60
- Registration Number
- NCT02314871
- Locations
- 🇨🇿
Brno University Hospital, Brno, Jihomoravsky Kraj, Czechia
🇨🇿T. Bata Regional Hospital Zlin, Zlin, Jihomoravsky Kraj, Czechia
Clinical Evaluation of the ReLeaf Analgesic Infusion Catheter & Wound Drain
- Conditions
- Interventions
- First Posted Date
- 2014-11-18
- Last Posted Date
- 2016-01-22
- Lead Sponsor
- Vital 5, LLC
- Registration Number
- NCT02293525
The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)
- First Posted Date
- 2014-11-17
- Last Posted Date
- 2019-01-11
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 111
- Registration Number
- NCT02292082
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain
- Conditions
- Interventions
- First Posted Date
- 2014-11-13
- Last Posted Date
- 2018-06-19
- Lead Sponsor
- Cukurova University
- Target Recruit Count
- 40
- Registration Number
- NCT02289261
- Locations
- 🇹🇷
Cukurova University Faculty of Medicine Research Hospital, Adana, Turkey
Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section
- First Posted Date
- 2014-10-31
- Last Posted Date
- 2014-10-31
- Lead Sponsor
- Central Hospital, Nancy, France
- Target Recruit Count
- 150
- Registration Number
- NCT02279628
- Locations
- 🇫🇷
Maternité Régionale Universitaire (MRU), Nancy, Lorraine, France
Intravenous Paracetamol for Postoperative Pain
- Conditions
- Interventions
- First Posted Date
- 2014-09-25
- Last Posted Date
- 2017-03-06
- Lead Sponsor
- Lithuanian University of Health Sciences
- Target Recruit Count
- 54
- Registration Number
- NCT02248493
- Locations
- 🇱🇹
Lithuanian University of Health Sciences Kaunas Clinics, Kaunas, Lithuania
Satisfactory Analgesia Minimal Emesis in Day Surgeries
- Conditions
- Interventions
- First Posted Date
- 2014-08-22
- Last Posted Date
- 2023-12-11
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 402
- Registration Number
- NCT02223377
- Locations
- 🇨🇦
Hamilton Health Sciences, Hamilton, Ontario, Canada
🇨🇦St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Multimodal Analgesia With Interfascial Continuous Wound Infiltration: A Randomized Clinical Trial
- Conditions
- Interventions
- First Posted Date
- 2014-08-22
- Last Posted Date
- 2014-08-22
- Lead Sponsor
- Hospital Galdakao-Usansolo
- Target Recruit Count
- 110
- Registration Number
- NCT02223533
- Locations
- 🇪🇸
Hospital de GAldakao-Usansolo, Usansolo, Biscay, Spain
Drug Development Updates
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