Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia
- Conditions
- Interventions
- First Posted Date
- 2020-12-31
- Last Posted Date
- 2022-12-21
- Lead Sponsor
- Łukasz Krzych
- Target Recruit Count
- 87
- Registration Number
- NCT04691726
- Locations
- 🇵🇱
Leszek Giec Upper-Silesia Medical Center of the Medical University of Silesia in Katowice, Katowice, Poland
Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2020-12-31
- Last Posted Date
- 2022-03-11
- Lead Sponsor
- Inonu University
- Target Recruit Count
- 66
- Registration Number
- NCT04691856
- Locations
- 🇹🇷
Sedat Akbas, Malatya, Türkiye-Türkçe, Turkey
Metabolomic Profiling of Erector Spinae Plane Block* for Breast Cancer Surgery
- Conditions
- Interventions
- First Posted Date
- 2020-12-30
- Last Posted Date
- 2023-01-19
- Target Recruit Count
- 91
- Registration Number
- NCT04689945
- Locations
- 🇹🇷
Dr.Abdurrahman Yurtaslan Ankara Oncology Train and Research Hospital, Ankara, Turkey
SEQ Block for Perioperative Analgesia in Acetabular Surgery
- First Posted Date
- 2020-12-30
- Last Posted Date
- 2022-03-03
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 52
- Registration Number
- NCT04688814
- Locations
- 🇪🇬
Alexandria Faculty of Medicine, Alexandria, Egypt
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine
- First Posted Date
- 2020-12-17
- Last Posted Date
- 2023-01-18
- Lead Sponsor
- Aalborg University
- Target Recruit Count
- 26
- Registration Number
- NCT04672382
- Locations
- 🇩🇰
Silvia Lo Vecchio, Aalborg, Nordjylland, Denmark
Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone and Post-operative Analgesia During Anal Sphincter Sparing Procedures Under General Anaesthesia
- Conditions
- Interventions
- First Posted Date
- 2020-12-03
- Last Posted Date
- 2022-10-20
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 26
- Registration Number
- NCT04651595
- Locations
- 🇪🇬
Kasr alainy medical school, CAiro, Egypt
Effects of Anaesthesia on Inflammatory Markers
- Conditions
- Interventions
- First Posted Date
- 2020-11-16
- Last Posted Date
- 2022-02-24
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 81
- Registration Number
- NCT04630938
- Locations
- 🇪🇬
Esam A. Hamed, Assiut, Egypt
Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine.
- Conditions
- Interventions
- First Posted Date
- 2020-11-05
- Last Posted Date
- 2021-03-01
- Lead Sponsor
- Minia University
- Target Recruit Count
- 60
- Registration Number
- NCT04618146
- Locations
- 🇪🇬
Minia university, Minya, Egypt
Dose Finding Study of STR-324
- First Posted Date
- 2020-10-12
- Last Posted Date
- 2021-07-13
- Lead Sponsor
- Alaxia SAS
- Target Recruit Count
- 118
- Registration Number
- NCT04582786
- Locations
- 🇳🇱
Leiden University Medical Center, Leiden, Netherlands
Opioid-Free Anesthetic for Tonsillectomy
- Conditions
- Interventions
- First Posted Date
- 2020-08-27
- Last Posted Date
- 2024-12-20
- Lead Sponsor
- Children's Hospital of Philadelphia
- Target Recruit Count
- 35
- Registration Number
- NCT04528173
- Locations
- 🇺🇸
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸University of Tennessee Health Science Center; St. Jude Children's Research Hospital, Memphis, Tennessee, United States
Drug Development Updates
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