Vindesine
- Generic Name
- Vindesine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C43H55N5O7
- CAS Number
- 53643-48-4
- Unique Ingredient Identifier
- RSA8KO39WH
- Background
Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols).
- Indication
For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis
- Associated Conditions
- Acute Lymphoblastic Leukemia (ALL), Blast crisis in myelogenous leukaemia, Malignant Melanoma
- Associated Therapies
- -
Trial of R-GemOx Versus R-miniCHOP Regimen in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma
- First Posted Date
- 2016-05-10
- Last Posted Date
- 2019-01-03
- Target Recruit Count
- 258
- Registration Number
- NCT02767674
- Locations
- ๐จ๐ณ
Shandong Province Hospital, Jinan, Shandong, China
๐จ๐ณTongji Medical College of HUST, Wuhan, Hubei, China
๐จ๐ณThe first Affiliated Hospital Of Nanjing Medical University(JiangSu Province Hospital), NanJing, Jiangsu, China
Combination Chemotherapy in Treating Young Adult Patients With Acute Lymphoblastic Leukemia
- Conditions
- First Posted Date
- 2010-07-05
- Last Posted Date
- 2021-09-13
- Target Recruit Count
- 76
- Registration Number
- NCT01156883
- Locations
- ๐ฎ๐น
Azienda Ospedaliera - Nuovo Ospedale "Torrette", Ancona, Italy
๐ฎ๐นUSL 8 - Ospedale S.Donato, Arezzo, Italy
๐ฎ๐นUO Ematologia con trapianto- AOU Policlinico Consorziale di Bari, Bari, Italy
International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia
- Conditions
- Interventions
- Drug: PEG-L-asparaginaseDrug: cyclophosphamideDrug: cytarabineDrug: daunorubicin hydrochlorideDrug: dexamethasoneDrug: doxorubicin hydrochlorideDrug: etoposideDrug: mercaptopurineDrug: ifosfamideDrug: methotrexateDrug: vincristine sulfateDrug: prednisoneRadiation: Radiation TherapyDrug: thioguanineDrug: vindesineDrug: daunoxomeDrug: fludarabine
- First Posted Date
- 2010-05-05
- Last Posted Date
- 2022-05-24
- Lead Sponsor
- University Hospital Schleswig-Holstein
- Target Recruit Count
- 6136
- Registration Number
- NCT01117441
- Locations
- ๐ฆ๐น
A.oe. Landeskrankenhaus Klagenfurt, Abt. fรผr Kinder- und Jugendheilkunde, Klagenfurt, Austria
๐จ๐ฟUniversity Hospital Brno, Department of Pediatric Oncology, Brno, Czechia
๐ฉ๐ชKlinikum Berlin-Buch II. Kinderklinik, Bereich Onkologie/Allg. Pรคdiatrie, Berlin, Germany
Three Different Therapy Regimens in Treating Patients With Previously Untreated Hodgkin Lymphoma
- Conditions
- Interventions
- Biological: bleomycin sulfateDrug: ABVD regimenDrug: cisplatinDrug: carmustineDrug: cytarabineDrug: dacarbazineDrug: dexamethasoneDrug: doxorubicin hydrochlorideDrug: etoposideDrug: gemcitabine hydrochlorideDrug: methylprednisoloneDrug: vincristine sulfateDrug: ifosfamideDrug: vindesineDrug: melphalanDrug: mitoguazoneDrug: vinorelbine tartrateProcedure: allogeneic hematopoietic stem cell transplantationProcedure: autologous hematopoietic stem cell transplantation
- First Posted Date
- 2009-06-15
- Last Posted Date
- 2016-09-16
- Lead Sponsor
- French Innovative Leukemia Organisation
- Target Recruit Count
- 442
- Registration Number
- NCT00920153
- Locations
- ๐ซ๐ท
FILO French Innovative Leukemia Organization, Tours Cedex, France
Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia
- Conditions
- Interventions
- Drug: asparaginaseDrug: cyclophosphamideDrug: cytarabineDrug: dexamethasoneDrug: daunorubicin hydrochlorideDrug: doxorubicin hydrochlorideDrug: methotrexateDrug: mercaptopurineDrug: thioguanineDrug: etoposideDrug: vincristine sulfateDrug: ifosfamideDrug: leucovorin calciumDrug: prednisoneDrug: vindesine
- First Posted Date
- 2008-10-02
- Last Posted Date
- 2009-07-08
- Lead Sponsor
- University Hospital, Motol
- Target Recruit Count
- 4000
- Registration Number
- NCT00764907
- Locations
- ๐จ๐ฟ
University Hospital Motol, Prague, Czech Republic
Combination Chemotherapy and Rituximab in Treating Patients With Primary Mediastinal Diffuse Large B-Cell Lymphoma
- Conditions
- Interventions
- First Posted Date
- 2008-06-04
- Last Posted Date
- 2009-07-08
- Target Recruit Count
- 120
- Registration Number
- NCT00689845
- Locations
- ๐ฌ๐ง
Leeds Cancer Centre at St. James's University Hospital, Leeds, England, United Kingdom
๐ฌ๐งChristie Hospital, Manchester, England, United Kingdom
๐ฌ๐งSouthampton General Hospital, Southampton, England, United Kingdom
Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia
- First Posted Date
- 2008-02-13
- Last Posted Date
- 2015-01-14
- Target Recruit Count
- 2039
- Registration Number
- NCT00613457
Combination Chemotherapy Followed by Stem Cell Transplant and Isotretinoin in Treating Young Patients With High-Risk Neuroblastoma
- Conditions
- First Posted Date
- 2007-09-10
- Last Posted Date
- 2015-07-16
- Target Recruit Count
- 360
- Registration Number
- NCT00526318
- Locations
- ๐ฉ๐ช
Klinikum Augsburg, Augsburg, Germany
๐ฉ๐ชEvangelisches Krankenhauus Bielfeld, Biefeld, Germany
๐ฉ๐ชKlinikum Duisburg, Duisburg, Germany
Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia
- Conditions
- Interventions
- Drug: asparaginaseDrug: cyclophosphamideDrug: cytarabineDrug: daunorubicin hydrochlorideDrug: dexamethasoneDrug: doxorubicin hydrochlorideDrug: ifosfamideDrug: etoposideDrug: mercaptopurineDrug: methotrexateDrug: prednisoneDrug: thioguanineDrug: vincristine sulfateDrug: vindesineRadiation: radiation therapy
- First Posted Date
- 2007-02-01
- Last Posted Date
- 2013-05-29
- Lead Sponsor
- University Hospital Schleswig-Holstein
- Target Recruit Count
- 4559
- Registration Number
- NCT00430118
- Locations
- ๐ฆ๐น
LKH Leoben, Leoben, Austria
๐ฆ๐นLandeskrankenhaus Feldkirch, Feldkirch-Tisis, Austria
๐ฆ๐นUniversitaet Kinderklinik, Graz, Austria
Observation, Combination Chemotherapy, Radiation Therapy, and/or Autologous Stem Cell Transplant in Treating Young Patients With Neuroblastoma
- Conditions
- First Posted Date
- 2006-12-13
- Last Posted Date
- 2013-08-07
- Target Recruit Count
- 642
- Registration Number
- NCT00410631
- Locations
- ๐ฉ๐ช
Kinderklinik - Universitaetsklinikum Aachen, Aachen, Germany
๐ฉ๐ชKlinikum Dortmund, Dortmund, Germany
๐ฉ๐ชKliniken der Stadt Koeln gGmbH - Kinderkrankenhaus Riehl, Cologne, Germany
Drug Development Updates
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