Sennosides
- Generic Name
- Sennosides
- Brand Names
- Colace, EX-lax Chocolated, EX-lax Maximum Relief Formula, EX-lax Regular Strength Pills, Laxacin, Little Tummys Laxative Drops, Perdiem Overnight, Peri-colace Reformulated Feb 2008, Senexon, Senexon S, Senna Lax, Senna-time, Senokot, Senokot-S
- Drug Type
- Small Molecule
- Chemical Formula
- C42H38O20
- CAS Number
- 517-43-1
- Unique Ingredient Identifier
- 3FYP5M0IJX
- Background
Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Sennoside A, one of the sennosides present in the laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human immunodeficiency virus (HIV) reverse transcriptase .
- Indication
For the over the counter treatment of constipation.
- Associated Conditions
- Autointoxication, Constipation, Haemorrhoids, Meteorism
- Associated Therapies
- -
Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery
- Conditions
- Rectal Cancer Surgery
- Interventions
- Drug: Sennosides colonic preparationDrug: Oral GentamycinDrug: Oral Placebo GentamycinDrug: Oral OrnidazoleDrug: Oral Placebo Ornidazole
- First Posted Date
- 2018-04-09
- Last Posted Date
- 2024-01-05
- Lead Sponsor
- Assistance Publique - HĂ´pitaux de Paris
- Target Recruit Count
- 414
- Registration Number
- NCT03491540
- Locations
- 🇫🇷
Service de chirurgie viscérale, cancérologique / Hôpital Saint-Louis, Paris, Ile De France, France
Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery
- Conditions
- Colon Cancer
- Interventions
- Drug: Sennosides colonic preparationDrug: Oral placebo GentamycinDrug: Oral GentamycinDrug: Oral placebo OrnidazoleDrug: Oral Ornidazole
- First Posted Date
- 2018-03-23
- Last Posted Date
- 2022-05-17
- Lead Sponsor
- Assistance Publique - HĂ´pitaux de Paris
- Target Recruit Count
- 193
- Registration Number
- NCT03475680
- Locations
- 🇫🇷
Service de chirurgie Colorectale / HĂ´pital Beaujon, Clichy, France
Drug Development Updates
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