Overview
Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Sennoside A, one of the sennosides present in the laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human immunodeficiency virus (HIV) reverse transcriptase .
Indication
For the over the counter treatment of constipation.
Associated Conditions
- Autointoxication
- Constipation
- Haemorrhoids
- Meteorism
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2018/04/09 | Phase 3 | Completed | |||
2018/03/23 | Phase 3 | Terminated | |||
2015/12/01 | Not Applicable | Completed | |||
2012/02/10 | Phase 4 | Completed | Medical University of Warsaw | ||
2009/05/14 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Geri-Care Pharmaceutical Corp | 57896-458 | ORAL | 8.6 mg in 1 1 | 3/24/2025 | |
| Granulation Technology, Inc. | 63561-0187 | ORAL | 8.6 mg in 1 1 | 7/30/2025 | |
| Bryant Ranch Prepack | 71335-1181 | ORAL | 8.6 mg in 1 1 | 4/29/2025 | |
| Major Pharmaceuticals | 0904-6725 | ORAL | 8.6 mg in 1 1 | 8/13/2025 | |
| PAI Holdings, LLC dba PAI Pharma | 0121-4967 | ORAL | 8.8 mg in 5 mL | 4/28/2025 | |
| Atlantis Consumer Healthcare, Inc. | 67618-110 | ORAL | 8.6 mg in 1 1 | 4/17/2025 | |
| ATLANTIC BIOLOGICALS CORP. | 17856-1127 | ORAL | 417.12 mg in 237 mL | 5/23/2025 | |
| ATLANTIC BIOLOGICALS CORP. | 17856-8237 | ORAL | 417.12 mg in 237 mL | 7/31/2025 | |
| Bi-Mart | 37835-214 | ORAL | 15 mg in 1 1 | 8/1/2025 | |
| Walgreens | 0363-8750 | ORAL | 8.6 mg in 1 1 | 5/7/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| SENNA TABLET 7.5 mg | SIN02550P | TABLET | 7.5 mg | 4/19/1989 | |
| SENOKOT TABLET 7.5 mg | SIN04731P | TABLET | 7.5 mg | 6/25/1990 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| EASUWEI SENNOSIDES TABLETS 20MG | N/A | N/A | N/A | 11/4/2024 | |
| SENCOLAX TAB 7.5MG | N/A | hysan pharmaceutical co ltd | N/A | N/A | 7/9/2010 |
| NEPURGO SENNOSIDES TABLETS 20MG | N/A | N/A | N/A | 11/4/2024 | |
| EFORMAT SENNOSIDES TABLETS 20MG | N/A | N/A | N/A | 11/4/2024 | |
| SURULAC-S ENTERIC-COATED TABLETS | N/A | N/A | N/A | 1/21/2013 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| LAXETTES SENNA LAXATIVE TABLETS blister pack | 12817 | Medicine | A | 8/22/1991 | |
| COLAXSEN film coated tablets bottle | 218552 | Medicine | A | 12/13/2013 | |
| APOHEALTH Laxative with Softener sennosides (as sennoside B) 8mg and docusate sodium 50mg film coated tablet bottle | 229304 | Medicine | A | 10/14/2014 | |
| CHEMISTS' OWN NATURAL LAXATIVE WITH SOFTENER tablet blister pack | 90442 | Medicine | A | 8/12/2002 | |
| AdMed Docu/Senna tablets bottle | 372287 | Medicine | A | 8/5/2021 | |
| SOLAX WITH SENNA tablet bottle | 456395 | Medicine | A | 7/25/2024 | |
| Coloxyl with senna tablets - HK | 337361 | Medicine | A | 6/2/2020 | |
| TERRYWHITE CHEMMART SENNALAX film coated tablet bottle | 309394 | Medicine | A | 9/18/2018 | |
| AMCAL SENNA-COL film coated tablet bottle (new formulation) | 231508 | Medicine | A | 12/5/2014 | |
| PHARMACY CHOICE SENNALAX film coated tablet bottle | 176296 | Medicine | A | 9/30/2010 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| SANDOZ SENNA S | 02247390 | Tablet - Oral | 8.6 MG | 12/10/2004 | |
| GLYSENNID TAB 8.6MG | novartis consumer health canada inc. | 00604402 | Tablet - Oral | 8.6 MG / TAB | 1/1/1979 |
| AGAROL WITH SENNOSIDES | numark laboratories, inc. | 02240031 | Liquid - Oral | 25 MG / 15 ML | 6/30/1999 |
| SD'S TEA | health way products | 00794309 | Tea (Herbal) - Oral | 10.5 MG / PCK | 12/31/1994 |
| NATURE'S REMEDY | glaxosmithkline consumer healthcare ulc | 02239460 | Tablet - Oral | 8.6 MG | 12/29/2000 |
| DOCUSEN | 02371650 | Tablet - Oral | 8.6 MG | N/A | |
| SENNA S. TABLETS | sigma life sciences inc. | 02246951 | Tablet - Oral | 8.6 MG | 10/29/2003 |
| LAXATIVE PLUS SOFTENER | cellchem pharmaceuticals inc. | 02322420 | Tablet - Oral | 8.6 MG | N/A |
| CHOLASYN | rolmex international inc. | 02236803 | Tablet - Oral | 12 MG | 6/29/1998 |
| JAMP-SENNA S | 02291215 | Tablet - Oral | 8.6 MG | 10/25/2010 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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