Sennosides
- Generic Name
- Sennosides
- Brand Names
- Colace, EX-lax Chocolated, EX-lax Maximum Relief Formula, EX-lax Regular Strength Pills, Laxacin, Little Tummys Laxative Drops, Perdiem Overnight, Peri-colace Reformulated Feb 2008, Senexon, Senexon S, Senna Lax, Senna-time, Senokot, Senokot-S
- Drug Type
- Small Molecule
- Chemical Formula
- C42H38O20
- CAS Number
- 517-43-1
- Unique Ingredient Identifier
- 3FYP5M0IJX
- Background
Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Sennoside A, one of the sennosides present in the laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human immunodeficiency virus (HIV) reverse transcriptase .
- Indication
For the over the counter treatment of constipation.
- Associated Conditions
- Autointoxication, Constipation, Haemorrhoids, Meteorism
Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery
- Conditions
- Rectal Cancer Surgery
- Interventions
- Drug: Oral Placebo GentamycinDrug: Oral Placebo Ornidazole
- First Posted Date
- 2018-04-09
- Last Posted Date
- 2024-01-05
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 414
- Registration Number
- NCT03491540
- Locations
- 🇫🇷
Service de chirurgie viscérale, cancérologique / Hôpital Saint-Louis, Paris, Ile De France, France
Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery
- Conditions
- Colon Cancer
- Interventions
- Drug: Oral placebo GentamycinDrug: Oral placebo Ornidazole
- First Posted Date
- 2018-03-23
- Last Posted Date
- 2022-05-17
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 193
- Registration Number
- NCT03475680
- Locations
- 🇫🇷
Service de chirurgie Colorectale / Hôpital Beaujon, Clichy, France
The Use of Sennosides With Pico Salax in Bowel Preparation for Colonoscopy: a Study of Optimal Dose and Timing
- First Posted Date
- 2015-12-01
- Last Posted Date
- 2018-05-09
- Lead Sponsor
- Queen's University
- Target Recruit Count
- 100
- Registration Number
- NCT02618564
- Locations
- 🇨🇦
Hotel Dieu Hospital, Kingston, Ontario, Canada
PEG Versus PEG+Bisacodyl Versus Sennosides for Colon Cleansing Before Colonoscopy
- Conditions
- Colonoscopy Preparation
- Interventions
- First Posted Date
- 2012-02-10
- Last Posted Date
- 2012-02-10
- Lead Sponsor
- Medical University of Warsaw
- Target Recruit Count
- 240
- Registration Number
- NCT01531140
- Locations
- 🇵🇱
Warsaw Medical University, Warsaw, Poland
🇵🇱Child Health Center, Warsaw, Poland
Effectiveness of Docusate in Preventing/Treating Constipation in Palliative Care Patients
- Conditions
- ConstipationPalliative Care
- Interventions
- First Posted Date
- 2009-05-14
- Last Posted Date
- 2011-04-20
- Lead Sponsor
- University of Alberta
- Target Recruit Count
- 70
- Registration Number
- NCT00902031
- Locations
- 🇨🇦
St. Joseph's Auxiliary Care Hospital, Edmonton, Alberta, Canada
🇨🇦CapitalCare Norwood, Edmonton, Alberta, Canada
🇨🇦Mel Miller Hospice at Edmonton General Continuing Care Hospital, Edmonton, Alberta, Canada
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.