Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Associated Therapies: -

Clinical Trials

Efficacy of Different Drugs to Control Post Root Canal Treatment Pain

Phase 2

Completed

Conditions: Postoperative Pain
Irreversible Pulpitis
Pain

Interventions: Procedure: Root Canal Treatment
Drug: Paracetamol
Drug: Ibuprofen
Drug: Mefenamic acid
Drug: Diclofenac

First Posted Date: 2015-04-15

Last Posted Date: 2015-04-15

Lead Sponsor: University of Khartoum

Target Recruit Count: 170

Registration Number: NCT02417337

Locations: 🇸🇩
University of Khartoum, Faculty of Dentistry,, Khartoum, Sudan

NSAIDS Versus Opioids in Acute SER II Ankle Fractures

Early Phase 1

Completed

Conditions: Ankle Fracture

Interventions: Drug: Acetaminophen/hydrocodone
Drug: Ibuprofen

First Posted Date: 2015-02-26

Last Posted Date: 2017-07-14

Lead Sponsor: University of California, Davis

Target Recruit Count: 1

Registration Number: NCT02373254

Locations: 🇺🇸
University of California Davis, Sacramento, California, United States

Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study)

Phase 2

Completed

Conditions: Retinopathy of Prematurity

Interventions: Drug: Caffeine citrate
Drug: Ketorolac
Drug: Ibuprofen

First Posted Date: 2015-01-22

Last Posted Date: 2020-05-01

Lead Sponsor: State University of New York - Downstate Medical Center

Target Recruit Count: 14

Registration Number: NCT02344225

Locations: 🇺🇸
SUNY Downstate Medical Center/University Hospital of Brooklyn, Brooklyn, New York, United States

Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

Phase 3

Completed

Conditions: Cachexia
Neoplasms

Interventions: Other: standard care
Other: nutritional supplements and advice
Other: home-based self-assisted exercise program
Drug: Ibuprofen

First Posted Date: 2015-01-05

Last Posted Date: 2024-06-04

Lead Sponsor: Norwegian University of Science and Technology

Target Recruit Count: 221

Registration Number: NCT02330926

Locations: 🇳🇴
St Olavs Hospital, Trondheim, Norway
🇬🇧
Queen Margaret Hospital, Dunfermline, Fife, United Kingdom
🇨🇦
Cross Cancer Insitute, Edmonton, Canada

and more 14 locations