Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Lignocaine Nebulization for Attenuation of Intubation Stress Response

Phase 4
Conditions
Interventions
First Posted Date
2020-06-22
Last Posted Date
2022-01-19
Lead Sponsor
Assiut University
Target Recruit Count
100
Registration Number
NCT04441073
Locations
🇪🇬

Assiut University, Assiut, Egypt

Intravenous Infusion of Lidocaine in Gastroscopy

Phase 4
Conditions
Interventions
First Posted Date
2020-06-19
Last Posted Date
2020-06-19
Lead Sponsor
Shandong University
Target Recruit Count
130
Registration Number
NCT04439773
Locations
🇨🇳

Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, China

Intravenous Infusion of Lidocaine in Colonoscopy

Phase 4
Conditions
Interventions
First Posted Date
2020-06-19
Last Posted Date
2020-06-19
Lead Sponsor
Shandong University
Target Recruit Count
50
Registration Number
NCT04439786
Locations
🇨🇳

Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, China

the Effect of Opioid-free General Anesthesia

First Posted Date
2020-06-01
Last Posted Date
2022-02-22
Lead Sponsor
The Catholic University of Korea
Target Recruit Count
78
Registration Number
NCT04409964
Locations
🇰🇷

Seoul St.Mary's Hospital, Seoul, Seocho-gu, Korea, Republic of

Improving Quality of Bier Block

First Posted Date
2020-05-19
Last Posted Date
2020-05-21
Lead Sponsor
Assiut University
Target Recruit Count
75
Registration Number
NCT04393610
Locations
🇪🇬

Assiut University Hospital, Assiut, Egypt

The Utility of Long-acting Local Anesthetic Agents in Reducing Post-operative Opioid Requirements Following Rhinoplasty

First Posted Date
2020-05-06
Last Posted Date
2023-03-23
Lead Sponsor
Our Lady of the Lake Hospital
Target Recruit Count
5
Registration Number
NCT04377204
Locations
🇺🇸

Our Lady of the Lake Hospital, Baton Rouge, Louisiana, United States

Steroid Injection for Adhesive Capsulitis

First Posted Date
2020-04-28
Last Posted Date
2020-05-14
Lead Sponsor
Taipei Veterans General Hospital, Taiwan
Target Recruit Count
80
Registration Number
NCT04364425
Locations
🇨🇳

Taipei veteran general hospital, Taipei, Taiwan

Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain

First Posted Date
2020-04-22
Last Posted Date
2024-03-29
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
33
Registration Number
NCT04356352
Locations
🇺🇸

Wake Forest Health Sciences, Winston-Salem, North Carolina, United States

Comparison of Ultrasound-guided Corticosteroid Injection Versus Corticosteroid Injection and Hydrodissection for Carpal Tunnel Syndrome

First Posted Date
2020-04-15
Last Posted Date
2020-04-21
Lead Sponsor
Taipei Veterans General Hospital, Taiwan
Target Recruit Count
60
Registration Number
NCT04346030
Locations
🇨🇳

Taipei veteran general hospital, Taipei, Taiwan

Quality of Recovery Following Opioids Free Anaesthesia in Laparoscopic Sleeve Gastrectomy

First Posted Date
2020-02-26
Last Posted Date
2021-11-08
Lead Sponsor
Al Mashfa Medical Center
Target Recruit Count
103
Registration Number
NCT04285255
Locations
🇸🇦

Al Mashfa medical center, Khobar, Eastern Provence, Saudi Arabia

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