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Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Intravitreal Injection Anesthesia - Comparison of Different Topical Agents

Not Applicable
Completed
Conditions
Age-Related Macular Degeneration (AMD)
Interventions
First Posted Date
2010-10-20
Last Posted Date
2012-04-19
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
92
Registration Number
NCT01224847
Locations
🇨🇦

Ivey Eye Institute, London, Ontario, Canada

Comparison Between Two Different Volumes of Anesthesia Drug in Forearm Surgery

Phase 3
Completed
Conditions
Forearm and Arm Surgery
Interventions
First Posted Date
2010-10-07
Last Posted Date
2011-12-21
Lead Sponsor
University Hospital, Brest
Target Recruit Count
72
Registration Number
NCT01216488
Locations
🇫🇷

Department of Anesthesia CHRU Brest, Brest, Brittany, France

Paracervical Block Before Intrauterine Device (IUD) Insertion

Not Applicable
Completed
Conditions
Pain Control for Intrauterine Device Insertions
Interventions
First Posted Date
2010-09-22
Last Posted Date
2013-06-10
Lead Sponsor
Northwestern University
Target Recruit Count
50
Registration Number
NCT01207401
Locations
🇺🇸

Northwestern Medical Faculty Foundation or Prentice Ambulatory Care Clinic, Chicago, Illinois, United States

IRB-HSR# 13957: IV Lidocaine for Patients Undergoing Primary Breast Cancer Surgery:

Phase 2
Completed
Conditions
Breast Cancer
Interventions
Drug: Placebo
Drug: Lidocaine
First Posted Date
2010-09-17
Last Posted Date
2022-03-24
Lead Sponsor
University of Virginia
Target Recruit Count
78
Registration Number
NCT01204242
Locations
🇺🇸

University of Virginia Health System, Charlottesville, Virginia, United States

MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains

Phase 3
Completed
Conditions
Ankle Sprains
Interventions
Drug: MRX-7EAT
Drug: Placebo
Drug: Lidocaine
Drug: Etodolac
First Posted Date
2010-09-10
Last Posted Date
2018-01-17
Lead Sponsor
MEDRx USA, Inc.
Target Recruit Count
600
Registration Number
NCT01198834

Topical Lidocaine on the Cervix and Intra-Cervical Prior to Insertion of Intrauterine Devices

Not Applicable
Conditions
Contraception
Interventions
Drug: Lidocaine
Drug: Lubricant
First Posted Date
2010-09-01
Last Posted Date
2011-06-16
Lead Sponsor
University of Tennessee
Target Recruit Count
210
Registration Number
NCT01192490
Locations
🇺🇸

University of Tennessee Chattanooga Department of Obstetrics and Gynecology, Chattanooga, Tennessee, United States

How Lidocaine Affects Outcomes In Orthopedic Surgery Patients

Phase 4
Withdrawn
Conditions
General Anesthesia
Surgeries Requiring A Minimum One Day Hospitalization
Elderly
Interventions
First Posted Date
2010-08-11
Last Posted Date
2015-09-07
Lead Sponsor
Cedars-Sinai Medical Center
Registration Number
NCT01179100
Locations
🇺🇸

Cedars Sinai Medical Center, Los Angeles, California, United States

Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine

Phase 2
Completed
Conditions
Colon Cancer
Inflammatory Bowel Diseases
Diverticulitis
Interventions
Procedure: Thoracic epidural block
Drug: Lidocaine
First Posted Date
2010-07-01
Last Posted Date
2011-11-28
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Target Recruit Count
60
Registration Number
NCT01155440
Locations
🇨🇦

MUHC, Montreal, Quebec, Canada

Lidocaine and Closed-Loop Anesthesia System

Phase 3
Completed
Conditions
Anesthesia
Interventions
Drug: Placebo
Drug: Lidocaine
First Posted Date
2010-07-01
Last Posted Date
2016-11-03
Lead Sponsor
Hopital Foch
Target Recruit Count
82
Registration Number
NCT01154738
Locations
🇫🇷

Hopital Tenon, Paris, France

Lidocaine Analgesia For Removal Of Wound Vac Dressings

Not Applicable
Completed
Conditions
Pain
Interventions
Drug: Lidocaine
Drug: Placebo-Saline
First Posted Date
2010-05-19
Last Posted Date
2014-05-29
Lead Sponsor
University of Utah
Target Recruit Count
11
Registration Number
NCT01126359
Locations
🇺🇸

University of Utah, Salt Lake City, Utah, United States

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