Medium-chain triglycerides

Overview

Medium-chain triglycerides (MCTs) are triglycerides made up of a glycerol backbone and three fatty acids with an aliphatic tail of six to 12 carbon atoms. MCTs are found in natural foods, such as coconut oil, palm kernel oil, and raw coconut meat. In the body, MCTs are broken down into glycerol and free fatty acids, which are directly absorbed into the blood stream and transported to the target organs to exert a range of biological and metabolic effects. MCTs are used in parenteral nutrition therapy: they serve as a source of calories and essential fatty acids in conditions associated with malnutrition and malabsorption.

Indication

Medium-chain triglycerides (MCTs), in combination with other compounds like fish oils, soya oil, and olive oil, is indicated in adult and pediatric patients, including term and preterm neonates, as a source of calories and essential fatty acids for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. MCTs are also available as over-the-counter natural products and health supplements.

Associated Conditions

No associated conditions information available.

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study	2019/10/17	NCT04129931	Phase 2	Completed	University of North Carolina, Chapel Hill
Adjuvant Vitamin D With Corticosteroids in Active Crohn's Disease	2008/05/06	NCT00672763	Phase 4	Withdrawn	Imperial College London

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Smoflipid	Fresenius Kabi USA, LLC	63323-820	INTRAVENOUS	6 g in 100 mL	8/30/2019

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
ENTRESTO FILM COATED TABLET 100MG	Novartis Pharma Stein AG, NOVARTIS SINGAPORE PHARMACEUTICAL MANUFACTURING PTE. LTD., Novartis Farma SpA	SIN14948P	TABLET, FILM COATED	100mg	2/12/2016
DEHYDRATED ALCOHOL INJECTION BP	Hospira Australia Pty Ltd	SIN06239P	INJECTION	100%	6/11/1991
NovoSeven® powder and solvent for solution for injection 2mg	Novo Nordisk A/S (DP and solvent in vials), Vetter Pharma-Fertigung GmbH & Co. KG (PFS Solvent)	SIN13934P	INJECTION, POWDER, FOR SOLUTION	2mg	3/17/2011
TRUMENBA SUSPENSION FOR INJECTION IN SINGLE-DOSE PRE-FILLED SYRINGE 0.5ML	Pfizer Ireland Pharmaceuticals	SIN15634P	INJECTION, SUSPENSION	0.06 mg/0.5ml	2/21/2019
IMOVAX POLIO INJECTION	SANOFI PASTEUR	SIN10608P	INJECTION	32 D.U./0.5 mL	1/6/1999
NovoSeven® powder and solvent for solution for injection 1mg	Novo Nordisk A/S (DP and solvent in vials), Novo Nordisk A/S, Vetter Pharma-Fertigung GmbH & Co. KG (PFS Solvent)	SIN13933P	INJECTION, POWDER, FOR SOLUTION	1mg	3/17/2011
PANVAX® PANDEMIC INFLUENZA VACCINE (ADJUVANTED) 10ML SUSPENSION FOR INJECTION VIAL	Seqirus Pty Ltd	SIN15801P	INJECTION, SUSPENSION	30 mcg HA / 0.5 ml	9/6/2019
NIMENRIX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION	Catalent Belgium S.A. (diluent in pre-filled syringe), Pfizer Manufacturing Belgium NV (diluent in pre-filled syringe), Pfizer Manufacturing Belgium NV, GlaxoSmithKline Biologicals SA	SIN14534P	INJECTION, POWDER, FOR SOLUTION	5 micrograms	4/3/2014
LACTEOL FORT CAPSULE	ADARE PHARMACEUTICALS SAS	SIN09791P	CAPSULE	80 mg	5/27/1998
SmofKabiven Emulsion for Infusion	Fresenius Kabi AB, Fresenius Kabi Austria GmbH	SIN14286P	INJECTION, EMULSION	60g /1000ml	1/8/2013

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
SMOFKABIVEN amino acids 5.1% / lipids 3.8% / glucose 12.7% / electrolytes 0.7% emulsion for intravenous infusion bag 1970 mL	180546	Fresenius Kabi Australia Pty Ltd	Medicine	A	1/9/2012
SMOFKABIVEN LOW OSMO amino acids 2.5%, electrolytes 0.4%, lipids 3.5% & glucose 6.8% emulsion for intravenous infusion 2500 mL biofine bag	329619	Fresenius Kabi Australia Pty Ltd	Medicine	A	8/27/2020
SMOFKABIVEN ELECTROLYTE FREE amino acids 5.1% / lipids 3.8% / glucose 12.7% emulsion for intravenous infusion bag 2463 mL	180550	Fresenius Kabi Australia Pty Ltd	Medicine	A	1/9/2012
SMOFKABIVEN ELECTROLYTE FREE amino acids 5.1% / lipids 3.8% / glucose 12.7% emulsion for intravenous infusion bag 986 mL	173891	Fresenius Kabi Australia Pty Ltd	Medicine	A	1/9/2012
SMOFKABIVEN LOW OSMO amino acids 2.5%, electrolytes 0.4%, lipids 3.5% & glucose 6.8% emulsion for intravenous infusion 1400 mL biofine bag	329617	Fresenius Kabi Australia Pty Ltd	Medicine	A	8/27/2020
SMOFKABIVEN amino acids 5.1% / lipids 3.8% / glucose 12.7% / electrolytes 0.7% emulsion for intravenous infusion bag 2463 mL	180547	Fresenius Kabi Australia Pty Ltd	Medicine	A	1/9/2012
SMOFKABIVEN ELECTROLYTE FREE amino acids 5.1% / lipids 3.8% / glucose 12.7% emulsion for intravenous infusion bag 1477 mL	180548	Fresenius Kabi Australia Pty Ltd	Medicine	A	1/9/2012
SMOFKABIVEN amino acids 5.1% / lipids 3.8% / glucose 12.7% / electrolytes 0.7% emulsion for intravenous infusion bag 1477 mL	180543	Fresenius Kabi Australia Pty Ltd	Medicine	A	1/9/2012
SMOFlipid (lipid emulsion) 20% emulsion for intravenous infusion 500 mL bag	158359	Fresenius Kabi Australia Pty Ltd	Medicine	A	3/24/2010
SMOFKABIVEN LOW OSMO amino acids 2.5%, electrolytes 0.4%, lipids 3.5% & glucose 6.8% emulsion for intravenous infusion1950 mL biofine bag	329618	Fresenius Kabi Australia Pty Ltd	Medicine	A	8/27/2020

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
No Health Canada approvals found for this drug.

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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