Naltrexone
- Generic Name
- Naltrexone
- Brand Names
- Contrave, Embeda, Vivitrol
- Drug Type
- Small Molecule
- Chemical Formula
- C20H23NO4
- CAS Number
- 16590-41-3
- Unique Ingredient Identifier
- 5S6W795CQM
- Background
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
- Indication
Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
- Associated Conditions
- Alcohol Dependency, Cholestatic pruritus, Obesity, Opioid Dependence, Severe Pain
Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)
- Conditions
- AlcoholismAlcohol DependenceDepression
- First Posted Date
- 2000-09-12
- Last Posted Date
- 2007-12-10
- Lead Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Target Recruit Count
- 106
- Registration Number
- NCT00006204
- Locations
- 🇺🇸
Department of Psychiatry, Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Sertraline for Alcohol Dependence and Depression
- Conditions
- AlcoholismDepression
- Interventions
- First Posted Date
- 2000-02-07
- Last Posted Date
- 2015-10-06
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 171
- Registration Number
- NCT00004554
- Locations
- 🇺🇸
Treatment Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Naltrexone Treatment for Alcoholic Women
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2014-05-07
- Lead Sponsor
- Yale University
- Target Recruit Count
- 160
- Registration Number
- NCT00000448
- Locations
- 🇺🇸
Substance Abuse Treatment Unit, Yale University, New Haven, Connecticut, United States
Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2013-01-29
- Lead Sponsor
- Yale University
- Target Recruit Count
- 198
- Registration Number
- NCT00000451
Behavioral Therapy Plus Naltrexone for Alcoholism
- Conditions
- AlcoholismAlcohol Dependence
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2010-10-04
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 160
- Registration Number
- NCT00000456
- Locations
- 🇺🇸
Medical Univ. of South Carolina, Charleston, South Carolina, United States
Naltrexone Treatment for Alcoholism
- Conditions
- Alcoholism
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2010-05-14
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 192
- Registration Number
- NCT00000438
- Locations
- 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States
Naltrexone for Early Problem Drinkers
- Conditions
- Alcoholism
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2011-06-20
- Lead Sponsor
- UConn Health
- Target Recruit Count
- 160
- Registration Number
- NCT00000455
- Locations
- 🇺🇸
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Naltrexone for Relapse Prevention
- Conditions
- Alcoholism
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2011-06-20
- Lead Sponsor
- UConn Health
- Target Recruit Count
- 57
- Registration Number
- NCT00000442
- Locations
- 🇺🇸
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)
- Conditions
- AlcoholismSmoking
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2010-10-01
- Target Recruit Count
- 200
- Registration Number
- NCT00000447
- Locations
- 🇺🇸
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, Texas, United States
Sertraline and Naltrexone for Alcohol Dependence
- Conditions
- Alcoholism
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Target Recruit Count
- 124
- Registration Number
- NCT00000440
- Locations
- 🇺🇸
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States
Drug Development Updates
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