Naltrexone

Generic Name
Naltrexone
Brand Names
Contrave, Embeda, Vivitrol
Drug Type
Small Molecule
Chemical Formula
C20H23NO4
CAS Number
16590-41-3
Unique Ingredient Identifier
5S6W795CQM
Background

Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.

Indication

Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.

Associated Conditions
Alcohol Dependency, Cholestatic pruritus, Obesity, Opioid Dependence, Severe Pain
Associated Therapies
-
Clinical Trials
Related News

Pharmacokinetic Characterization of the Active, Separated System With PK Controller (Fentanyl Iontophoretic Transdermal System, 40 Mcg Fentanyl Per Activation).

Phase 1
Completed
Conditions
Pain, Postoperative
Interventions
Drug: Fentanyl
Drug: Naltrexone
First Posted Date
2012-12-17
Last Posted Date
2013-04-19
Lead Sponsor
Incline Therapeutics, Inc.
Target Recruit Count
54
Registration Number
NCT01750060
Locations
🇺🇸

PRACS Institute, Ltd., Fargo, North Dakota, United States

A Double-Blind Comparison of Naltrexone and Placebo in Adults With Attention Deficit Hyperactivity Disorder

First Posted Date
2012-11-04
Last Posted Date
2016-05-27
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
3
Registration Number
NCT01721330
Locations
🇺🇸

Massachusetts General Hospital, Cambridge, Massachusetts, United States

Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist

First Posted Date
2012-08-28
Last Posted Date
2016-11-30
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
37
Registration Number
NCT01673594
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

Neuropharmacological Basis of Social Connection: The Role of Opioids

Not Applicable
Completed
Conditions
Psychology, Social
Interventions
Drug: Naltrexone
First Posted Date
2012-08-27
Last Posted Date
2016-01-14
Lead Sponsor
University of California, Los Angeles
Target Recruit Count
34
Registration Number
NCT01672723
Locations
🇺🇸

University of California, Los Angeles Department of Psychology, Los Angeles, California, United States

Low Dose Naltrexone for Metastatic Melanoma, Castrate Resistant Prostate Cancer and Renal Cancer

Phase 2
Terminated
Conditions
Melanoma
Prostate Cancer
Renal Cancer
Interventions
Drug: Naltrexone
First Posted Date
2012-07-26
Last Posted Date
2022-03-04
Lead Sponsor
Brown University
Target Recruit Count
7
Registration Number
NCT01650350
Locations
🇺🇸

Miriam Hospital, Providence, Rhode Island, United States

Pharmacotherapy for Alcohol Dependence in Convicted Drinking Drivers

Phase 4
Terminated
Conditions
Alcohol Dependence
Interventions
Drug: Naltrexone
Drug: Control
First Posted Date
2012-07-11
Last Posted Date
2014-04-02
Lead Sponsor
Centre for Addiction and Mental Health
Target Recruit Count
2
Registration Number
NCT01638377
Locations
🇨🇦

Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors

Phase 1
Completed
Conditions
Alcohol Drinking
Interventions
Drug: Naltrexone
First Posted Date
2012-06-21
Last Posted Date
2022-08-10
Lead Sponsor
Yale University
Target Recruit Count
59
Registration Number
NCT01625611
Locations
🇺🇸

Sac, Cmhc, New Haven, Connecticut, United States

Clinical Trial to Reduce Drinking in Women With HIV

Phase 3
Completed
Conditions
HIV Infection
Interventions
Drug: Placebo
Drug: Naltrexone
First Posted Date
2012-06-21
Last Posted Date
2018-07-10
Lead Sponsor
University of Florida
Target Recruit Count
194
Registration Number
NCT01625091
Locations
🇺🇸

Florida International University, Miami, Florida, United States

🇺🇸

University of Miami, Coral Gables, Florida, United States

CURE Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery

Phase 2
Completed
Conditions
Prescription Opiate/Medication Dependence
Interventions
Drug: Vivitrol
First Posted Date
2012-04-30
Last Posted Date
2024-10-11
Lead Sponsor
University of Pennsylvania
Target Recruit Count
72
Registration Number
NCT01587196
Locations
🇺🇸

University of Pennsylvania Addiction Treatment Research Center, Philadelphia, Pennsylvania, United States

The Effects of Treatment With Naltrexone in Alcohol and Cannabis-dependent Patients

Not Applicable
Conditions
Alcohol-dependence
Interventions
Drug: Naltrexone
First Posted Date
2012-03-21
Last Posted Date
2012-03-21
Lead Sponsor
Tel-Aviv Sourasky Medical Center
Target Recruit Count
24
Registration Number
NCT01560013
Locations
🇮🇱

Dept. of Nuclear Medicine, TASMC, Tel Aviv, Israel

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