Methylene blue

Generic Name: Methylene blue

Brand Names: Hyophen, Phosphasal, Provayblue, Proveblue, Urelle, Uribel, Urimar Reformulated Oct 2013, Urin DS, Urogesic Blue Reformulated Apr 2012, Ustell, Utira, Lumeblue (previously known as Methylthioninium chloride Cosmo), Methylthioninium chloride Proveblue

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₈ClN_₃S

CAS Number: 61-73-4

Unique Ingredient Identifier: 8NAP7826UB

Background: Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs entered the market. Its use as an urinar...

Indication: Indicated for the treatment of pediatric and adult patients with acquired methemoglobinemia.
...

Associated Conditions: Cystitis, Methemoglobinemia, Nephritis, Urethritis, Urinary tract inflammation

Associated Therapies: Diuresis

Clinical Trials

Use of Indocyanine Green Cholangiography and Methylene Blue to Detect Postoperative Biliary Fistula After Hepatectomy

Phase 3

Conditions: Liver Disease

Interventions: Procedure: indocyanine green fluorescent cholangiography
Drug: methylene blue

First Posted Date: 2013-05-07

Last Posted Date: 2018-08-21

Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Target Recruit Count: 132

Registration Number: NCT01847612

Locations: 🇫🇷
Amiens University Hospital, Amiens, France

Laparoscopic Tubal Patency Assessment

Not Applicable

Completed

Conditions: Methylene Blue
Laparoscopy
Tubal Patency

Interventions: Drug: methylen blue &normal saline
Drug: methylene blue
Drug: metheylne blue with normal saline

First Posted Date: 2012-11-12

Last Posted Date: 2017-04-11

Lead Sponsor: Pourmatroud, Elham, M.D.

Target Recruit Count: 30

Registration Number: NCT01725477

Locations: 🇮🇷
Ahvaz Jundishapur university of medical science, Ahvaz, Iran, Islamic Republic of

The Influence of Endotracheal Tube Design on Fluid Leakage Into the Lungs During Surgery

Not Applicable

Completed

Conditions: Respiratory Aspiration

Interventions: Drug: Methylene Blue

First Posted Date: 2012-02-27

Last Posted Date: 2015-08-13

Lead Sponsor: Medtronic - MITG

Target Recruit Count: 80

Registration Number: NCT01539135

Locations: 🇺🇸
Tulane University Hospital and Clinics, New Orleans, Louisiana, United States

Evaluation of Above the Cuff Suctioning During General Anesthesia

Phase 4

Terminated

Conditions: Secretion Removal Above ETT Cuff

Interventions: Drug: methylene blue

First Posted Date: 2011-07-01

Last Posted Date: 2022-06-08

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 50

Registration Number: NCT01386879

Locations: 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Sentinel and/or Axillary Lymph Node Biopsy With or Without Axillary Reverse Mapping in Reducing Incidence and Severity of Arm Lymphedema in Stage 0-2 Patients.

Phase 2

Terminated

Conditions: Recurrent Breast Cancer
Stage IA Breast Cancer
Stage II Breast Cancer
Lymphedema
Stage IB Breast Cancer

Interventions: Radiation: technetium Tc 99m sulfur colloid
Drug: methylene blue
Drug: indocyanine green solution
Procedure: sentinel lymph node biopsy
Procedure: axillary lymph node biopsy
Procedure: bioimpedance spectroscopy
Procedure: quality-of-life assessment
Other: lymphedema management

First Posted Date: 2011-01-13

Last Posted Date: 2014-08-01

Lead Sponsor: University of Southern California

Target Recruit Count: 4

Registration Number: NCT01276054

Locations: 🇺🇸
USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States

Feasibility of One-Step Sentinel Lymph Node (SLN) Biopsy With Radiolabeled Methylene Blue (IND 70,627)

Phase 2

Completed

Conditions: Breast Cancer

Interventions: Drug: Methylene blue

First Posted Date: 2008-11-04

Last Posted Date: 2012-06-20

Lead Sponsor: Louisiana State University Health Sciences Center in New Orleans

Target Recruit Count: 62

Registration Number: NCT00784849

Locations: 🇺🇸
University Medical Center, Lafayette, Louisiana, United States
🇺🇸
LSU Interim Hospital, New Orleans, Louisiana, United States

Interaction Between Anaesthetics and Methylene Blue

Completed

Conditions: Hyperparathyroidism

Interventions: Drug: methylene blue

First Posted Date: 2007-08-08

Last Posted Date: 2007-08-08

Lead Sponsor: University Hospital, Geneva

Target Recruit Count: 22

Registration Number: NCT00513032

Locations: 🇨🇭
Service d'Anesthésiologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest, Geneva, Switzerland

Methylene Blue in Sepsis: A Randomized Controlled Trial

Not Applicable

Withdrawn

Conditions: Sepsis

Interventions: Drug: methylene blue

First Posted Date: 2007-06-14

Last Posted Date: 2008-05-29

Lead Sponsor: Queen's University

Registration Number: NCT00486174

Safety and Efficacy of Methylene Blue Combined With Artesunate or Amodiaquine for Malaria Treatment in Children of Burkina Faso: a Pilot Study

Phase 2

Completed

Conditions: Malaria

First Posted Date: 2006-07-20

Last Posted Date: 2006-10-24

Lead Sponsor: Heidelberg University

Registration Number: NCT00354380

Locations: 🇧🇫
Nouna District Hospital, Nouna, Burkina Faso

Methylene Blue for Cognitive Dysfunction in Bipolar Disorder

Phase 3

Completed

Conditions: Bipolar Disorder

First Posted Date: 2005-09-22

Last Posted Date: 2008-04-01

Lead Sponsor: Nova Scotia Health Authority

Target Recruit Count: 40

Registration Number: NCT00214877

Locations: 🇨🇦
St. Joseph's Healthcare, Hamilton, Ontario, Canada
🇨🇦
CDHA- QE II Health Sciences Centre, Halifax, Nova Scotia, Canada

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