哌拉西林 (Pipracil, Zosyn)

概览

Piperacillin is a penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.

作用机制

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.

适应症

For the treatment of polymicrobial infections.

• Animal bite
• Bacterial Infections
• Bone and Joint Infections
• Community Acquired Pneumonia (CAP)
• Gynecological Infection
• Infection, Mixed
• Intraabdominal Infections
• Lower Respiratory Tract Infection (LRTI)
• Nosocomial Pneumonia
• Pelvic Infections
• Septicemia
• Skin and skin structure infections